Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity.
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity.
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DOI：
10.1242/dev.01724
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发表时间：
2005-04
期刊：
影响因子：
--
通讯作者：
Martinez Arias A
中科院分区：
文献类型：
--
作者：
Hayward P;Brennan K;Sanders P;Balayo T;DasGupta R;Perrimon N;Martinez Arias A
发育过程中细胞命运的建立和稳定依赖于多种信号的整合，这些信号最终调节特定的基因表达模式。虽然在基因调控序列的水平上有充分的证据证明这种整合，但对它在细胞活动的其他水平上的运作知之甚少。WNT和Notch信号是调节发育和疾病中基因表达的电路的重要元件。遗传分析表明，除了特定基因转录上的趋同外，这些信号通路之间还存在着相互调节的交叉调节作用。在这里，我们报道这些相互作用的结点是Notch的活性，它调节Armadillo/？-catenin的活性和活性/致癌形式的量。Notch的这种活性不依赖于其胞内区的裂解所诱导的活性，而是通过SU(H)/CBF1介导转录。这里描述的Notch的调制功能有助于为Wnt信号建立一个健壮的阈值，这可能在正常和病理情况下都发挥重要作用
The establishment and stability of cell fates during development depend on the integration of multiple signals, which ultimately modulate specific patterns of gene expression. While there is ample evidence for this integration at the level of gene regulatory sequences, little is known about its operation at other levels of cellular activity. Wnt and Notch signalling are important elements of the circuitry that regulates gene expression in development and disease. Genetic analysis has suggested that in addition to convergence on the transcription of specific genes, there are modulatory cross regulatory interactions between these signalling pathways. Here we report that the nodal point of these interactions is an activity of Notch which regulates the activity and the amount of the active/oncogenic form of Armadillo/ß-catenin. This activity of Notch is independent of that induced upon cleavage of its intracellular domain and which mediates transcription through Su(H)/CBF1. The modulatory function of Notch described here, contributes to the establishment of a robust threshold for Wnt signalling which is likely to play important roles in both normal and pathological situations
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影响因子：
9.2
作者：
Furriols, M;Bray, S
通讯作者：
Bray, S
影响因子：
8
作者：
Brennan, K;Gonzalez-Sancho, JM;Castelo-Soccio, LA;Howe, LR;Brown, AMC
通讯作者：
Brown, AMC
影响因子：
2.6
作者：
DECELIS, JF;GARCIABELLIDO, A
通讯作者：
GARCIABELLIDO, A
影响因子：
9.2
作者：
Gottardi, CJ;Gumbiner, BM
通讯作者：
Gumbiner, BM
影响因子：
11.4
作者：
Arias, AM
通讯作者：
Arias, AM