Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.
Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.
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DOI：
10.4049/jimmunol.1200702
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发表时间：
2012-09-01
期刊：
影响因子：
--
通讯作者：
Kearney JF
中科院分区：
文献类型：
--
作者：
Kin NW;Stefanov EK;Dizon BL;Kearney JF
在发达国家，过敏性哮喘和与哮喘有关的死亡人数急剧上升;与此相反，许多儿童疾病已经减少或消除。卫生假说提出，生命早期的过度卫生条件会导致自身免疫和过敏现象，因为免疫系统在发育过程中无法接受适当的微生物刺激。我们证明，对保守的细菌多糖产生的抗体与几丁质和烟曲霉菌的免疫反应和抑制。在抗多糖抗体存在下，抗原摄取、细胞流入、细胞活化和细胞因子产生减少，导致小鼠过敏性气道疾病的严重程度显著降低。总体而言，我们的研究结果表明，抗原暴露在新生儿期，来自环境来源，自身抗原，或疫苗接种，有显着的影响成人抗体反应和修改过敏性气道疾病的发展。
There has been a sharp rise in allergic asthma and asthma-related deaths in the developed world; in contrast to many childhood illnesses that have been reduced or eliminated. The hygiene hypothesis proposes that excessively sanitary conditions early in life result in autoimmune and allergic phenomena because of a failure of the immune system to receive proper microbial stimulation during development. We demonstrate that antibodies generated against conserved bacterial polysaccharides are reactive with and dampen the immune response against chitin and Aspergillus fumigatus. A reduction in antigen uptake, cell influx, cell-activation, and cytokine production occurred in the presence of anti-polysaccharide antibodies, resulting in a striking decrease in the severity of allergic airway disease in mice. Overall, our results suggest that antigen exposure during the neonatal period, derived from environmental sources, self-antigens, or vaccination, have dramatic effects on the adult antibody response and modify the development of allergic airway disease.
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在聚合物免疫球蛋白受体/分泌成分缺陷的小鼠中，缺乏上皮免疫球蛋白A转运，粘膜泄漏增加。
影响因子：
15.3
作者：
Johansen, F E;Pekna, M;Norderhaug, I N;Haneberg, B;Hietala, M A;Krajci, P;Betsholtz, C;Brandtzaeg, P
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Brandtzaeg, P
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120.1
作者：
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通讯作者：
Schenerman, Mark
影响因子：
11.5
作者：
Dadachova, Ekaterina;Bryan, Ruth A.;Casadevall, Arturo
通讯作者：
Casadevall, Arturo
影响因子：
4.4
作者：
Bozza, Silvia;Clavaud, Cecile;Romani, Luigina
通讯作者：
Romani, Luigina
影响因子：
158.5
作者：
Chupp, Geoffrey L.;Lee, Chun Geun;Elias, Jack A.
通讯作者：
Elias, Jack A.