Catalytic antibodies in the bone marrow and other organs of Th mice during spontaneous development of experimental autoimmune encephalomyelitis associated with cell differentiation.
Catalytic antibodies in the bone marrow and other organs of Th mice during spontaneous development of experimental autoimmune encephalomyelitis associated with cell differentiation.
复制标题
DOI：
10.1007/s11033-020-06117-8
复制
发表时间：
2021-03
影响因子：
2.8
通讯作者：
Nevinsky GA
中科院分区：
文献类型：
--
作者：
Aulova KS;Urusov AE;Toporkova LB;Sedykh SE;Shevchenko YA;Tereshchenko VP;Sennikov SV;Budde T;Meuth SG;Orlovskaya IA;Nevinsky GA
自身免疫性疾病发展的确切机制仍然是未知的。然而，已知自身免疫性疾病的发展与免疫系统的缺陷相关，即骨髓造血干细胞（HSC）分化谱的破坏。实验性自身免疫性脑脊髓炎（EAE）易感Th小鼠的自身免疫反应发展的不同特点，表征T淋巴细胞反应进行了分析，使用标准的方法。在自发性EAE发病过程中，Th系小鼠骨髓造血干细胞（BFU-E、CFU-E、CFU-GM、CFU-GEMM、T淋巴细胞和B淋巴细胞）的分化特征明显不同。几种不同器官（骨髓、血液、脾脏、胸腺和淋巴结）中的总淋巴细胞、B细胞和T细胞增殖模式也明显不同。此外，雌雄小鼠某些器官的变化在时间上存在明显差异。某些器官中CD_4和CD_8细胞增殖曲线的变化特征并不总是与总T淋巴细胞的变化特征相一致。造血干细胞分化谱和骨髓及其他器官淋巴细胞增殖水平的变化与抗DNA、髓鞘碱性蛋白和髓鞘少突胶质细胞糖蛋白抗体浓度的增加以及水解这些底物的催化抗体有关。尽管分析参数的变化存在一些差异，但一般而言，雄性和雌性小鼠中EAE的自发发生在一定程度上具有可比性。
Exact mechanisms of autoimmune disease development are still yet unknown. However, it is known that the development of autoimmune diseases is associated with defects in the immune system, namely, the violation of the bone marrow hematopoietic stem cells (HSCs) differentiation profiles. Different characteristics of autoimmune reaction development in experimental autoimmune encephalomyelitis (EAE) prone Th mice characterizing T-lymphocytes response were analyzed using standard approaches. Profiles of several HSCs differentiation of bone marrow (BFU-E, CFU-E, CFU-GM, CFU-GEMM, T- and B-lymphocytes) of Th male and female mice during spontaneous development of EAE were noticeably different. Patterns of total lymphocytes, B- and T-cells proliferation in several different organs (bone marrow, blood, spleen, thymus, and lymph nodes) were also remarkably different. In addition, there were in time noticeable differences in their changes for some organs of male and female mice. Characters of changes in the profiles of CD4 and CD8 cells proliferation in some organs not always coincide with those for total T lymphocytes. The changes in the differentiation profiles of HSCs and the level of lymphocytes proliferation in the bone marrow and other organs were associated with the increase in the concentration of antibodies against DNA, myelin basic protein, and myelin oligodendrocyte glycoprotein, and catalytic antibodies hydrolyzing these substrates. Despite some differences in changes in the analyzed parameters, in general, the spontaneous development of EAE in male and female mice occurs to some extent in a comparable way.
登录
查看更多内容
影响因子：
3.7
作者：
Doronin, Vasilii B.;Parkhomenko, Taisiya A.;Nevinsky, Georgy A.
通讯作者：
Nevinsky, Georgy A.
影响因子：
5.3
作者：
Aulova, Kseniya S.;Toporkova, Ludmila B.;Nevinsky, Georgy A.
通讯作者：
Nevinsky, Georgy A.
影响因子：
3.5
作者：
Andryushkova, Alexandra A.;Kuznetsova, Irina A.;Nevinsky, Georgy A.
通讯作者：
Nevinsky, Georgy A.
影响因子：
4.4
作者：
Baranovskii, AG;Ershova, NA;Nevinsky, GA
通讯作者：
Nevinsky, GA
影响因子：
2.7
作者：
Bezuglova, Anna M.;Konenkova, Ludmila P.;Nevinsky, Georgy A.
通讯作者：
Nevinsky, Georgy A.