A home-based exercise intervention to increase physical activity among people living with HIV: study design of a randomized clinical trial.
A home-based exercise intervention to increase physical activity among people living with HIV: study design of a randomized clinical trial.
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DOI：
10.1186/1471-2458-13-502
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发表时间：
2013-05-24
影响因子：
4.5
通讯作者：
Hand GA
中科院分区：
文献类型：
--
作者：
Jaggers JR;Dudgeon W;Blair SN;Sui X;Burgess S;Wilcox S;Hand GA
虽然抗逆转录病毒联合疗法延长了人类免疫缺陷病毒（艾滋病毒）感染者的预期寿命，但合并症的发病率很高，增加了艾滋病毒/艾滋病（艾滋病毒/艾滋病）感染者心血管疾病发病率和死亡率的风险。与抗逆转录病毒疗法（ART）相关的副作用导致多种代谢紊乱，使这些代谢问题的管理和接受ART治疗的患者的心血管疾病（CVD）风险成为一个关键问题。临床研究试验，主要是临床练习，很少包括这一人群，因为研究方法面临独特的挑战，少数群体患有威胁生命的疾病，如艾滋病毒/艾滋病。本文介绍了一项随机临床试验的原理和设计，该试验评估了旨在增加体力活动（PA）和降低PLWHA中CVD风险的家庭锻炼计划的可行性。正在接受抗逆转录病毒治疗的艾滋病毒感染者将被随机分配到两组之一：家庭PA干预或标准护理。所有参与者都将收到一本教育减肥手册和计步器，用于自我监测PA。只有那些在干预组将获得额外的弹性Thera-bands®的力量训练和行为电话为基础的教练。这项研究将评估旨在增加艾滋病毒/艾滋病感染者的PA的家庭方案的可行性。此外，它将评估这种计划的有效性，以减少CVD的可改变的风险因素作为次要结局。该研究由NIH/NINR R21 Grant 1 R21 NRO 11281资助。临床试验标识符NCT 01377064
While combination antiretroviral therapy has extended the life expectancy of those infected with human immunodeficiency virus (HIV), there is a high prevalence of comorbidities that increase the risk of cardiovascular morbidity and mortality among people living with HIV/AIDS (PLWHA). The side effects associated with antiretroviral therapy (ART) lead to multiple metabolic disorders, making the management of these metabolic issues and risk of cardiovascular disease (CVD) in those treated with ART a critical issue. Clinical research trials, primarily clinical exercise, rarely include this population due to unique challenges in research methods with underserved minority populations living with a life threatening illness like HIV/AIDS. This paper describes the rationale and design of a randomized clinical trial evaluating the feasibility of a home-based exercise program designed to increase physical activity (PA) and reduce the risk of CVD in PLWHA. PLWHA being treated with ART will be randomly assigned to one of two groups: a home-based PA intervention or standard care. All participants will receive an educational weight loss workbook and pedometer for self-monitoring of PA. Only those in the intervention group will receive additional elastic Thera-bands® for strength training and behavioral telephone based coaching. This study will evaluate the feasibility of a home-based program designed to increase PA among PLWHA. Further, it will evaluate the effectiveness of such a program to decrease modifiable risk factors for CVD as a secondary outcome. This study was funded by the NIH/NINR R21 Grant 1R21NRO11281. Clinical Trial Identifier NCT01377064
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1080/09540120701796900
发表时间：
2008-10-01
影响因子：
1.7
作者：
Hand, Gregory A.;Phillips, Kenneth D.;Burgess, Stephanie E.
通讯作者：
Burgess, Stephanie E.
DOI：
10.1249/01.mss.0000175865.17614.74
发表时间：
2005-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Jurca, R;Lamonte, MJ;Blair, SN
通讯作者：
Blair, SN
影响因子：
120.7
作者：
Blair, SN;Kampert, JB;Gibbons, LW
通讯作者：
Gibbons, LW
影响因子：
2.4
作者：
GARCIA, AW;KING, AC
通讯作者：
KING, AC