NONLINEAR DETERMINISM IN THE IMMUNE SYSTEM. IN VIVO INFLUENCE OF ELECTROMAGNETIC FIELDS ON DIFFERENT FUNCTIONS OF MURINE LYMPHOCYTE SUBPOPULATIONS*
NONLINEAR DETERMINISM IN THE IMMUNE SYSTEM. IN VIVO INFLUENCE OF ELECTROMAGNETIC FIELDS ON DIFFERENT FUNCTIONS OF MURINE LYMPHOCYTE SUBPOPULATIONS*
复制标题
免疫系统中的非线性决定论。
DOI：
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发表时间：
2001
影响因子：
2.8
通讯作者：
C. Frilot
中科院分区：
文献类型：
--
作者：
Andrew A. Marino;R. Wolcott;R. Chervenak;F. Jourd’heuil;E. Nilsen;C. Frilot
低频电磁场（emf）对免疫系统影响的动物研究似乎不一致，最近的证据表明，不明显的实验问题不是原因。我们假设不一致是由于使用线性方法和模型来研究固有的非线性投入产出关系。使用一种新的分析方法，我们发现，在6个独立实验中，小鼠暴露于5 G， 60 Hz， 1-105天，持续影响广泛的免疫变量，当且仅当免疫系统的反应建模时，允许电场和免疫变量之间的关系存在非线性的可能性。通过从已知的混沌系统中采样，可以模拟在免疫数据中观察到的模式，这表明观察到的模式可能是免疫系统内在非线性调节机制的结果。总体而言，结果表明淋巴细胞亚群易受EMF转导的生理后果的影响，可能永远不可能预测特定免疫系统变量的特定变化，并且免疫系统的潜在行为（在缺乏特定输入的情况下发生的行为）可能受对先前状态表现出极端敏感性的规律支配。
Animal studies of the effects of low-frequency electromagnetic fields (EMFs) on the immune system appear inconsistent and recent evidence indicates that inconspicuous experimental problems are not responsible. We hypothesized that the inconsistencies resulted from use of linear methods and models to study inherently nonlinear input-output relationships. Using a novel analytical method, we found that exposure of mice to 5 G, 60 Hz, for 1–105 days in 6 independent experiments consistently affected a broad panel of immune variables when and only when the reaction of the immune system was modeled to allow the possibility of nonlinearity in the relationship between the field and the immune variables. It was possible to mimic the pattern observed in the immune data by sampling from a known chaotic system, suggesting the possibility that the observed pattern was the result of intrinsic nonlinear regulatory mechanisms in the immune system. Overall, the results suggested that lymphoid sub-populations were vulnerable to the physiological consequences of EMF transduction, that it may never be possible to predict specific changes in particular immune-system variables, and that the underlying behavior of the immune system (that which occurs in the absence of specific inputs) may be governed by laws that manifest extreme sensitivity to prior states.
在子宫内接触乙醇会影响 T 淋巴细胞和 B 淋巴细胞的出生后发育，但不会影响自然杀伤细胞。
DOI：
10.1111/j.1530-0277.1995.tb01487.x
发表时间：
1995
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
Wolcott,RM;Jennings,SR;Chervenak,R
通讯作者：
Chervenak,R
DOI：
10.1073/pnas.95.25.14926
发表时间：
1998-12-08
影响因子：
11.1
作者：
Antia, R;Pilyugin, SS;Ahmed, R
通讯作者：
Ahmed, R
儿童接触用于观看节目和玩视频游戏的美国电视机产生的磁场。
影响因子：
1.9
作者：
Kaune,WT;Miller,MC;Linet,MS;Hatch,EE;Kleinerman,RA;Wacholder,S;Mohr,AH;Tarone,RE;Haines,C
通讯作者：
Haines,C