Pseudo Test-Retest Evaluation of Millimeter-Resolution Whole-Brain Dynamic Contrast-enhanced MRI in Patients with High-Grade Glioma.
Pseudo Test-Retest Evaluation of Millimeter-Resolution Whole-Brain Dynamic Contrast-enhanced MRI in Patients with High-Grade Glioma.
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DOI：
10.1148/radiol.2021203628
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发表时间：
2021-08
期刊：
影响因子：
19.7
通讯作者：
Nayak KS
中科院分区：
文献类型：
--
作者：
Bliesener Y;Lebel RM;Acharya J;Frayne R;Nayak KS
亚奈奎斯特采样动态对比增强（DCE）MRI的进步使脑肿瘤的监测具有毫米分辨率和全脑覆盖。这种欠采样的定量方法需要仔细表征可实现的重测重现性。证明具有30倍稀疏欠采样的全自动高分辨率全脑DCE MRI管道，并通过使用高级别胶质瘤的纵向临床图像，在多个治疗后时间点期间基于稳定组织类型的参考区域估计其再现性。通过血管输入函数的自动估计，扩展了用于亚奈奎斯特采样DCE MRI的两种方法。连续采集的三维k空间数据与倾斜上升的翻转角进行分区，以产生高分辨率，全脑示踪剂动力学参数地图与匹配的造影剂前T1和M0地图。在一项回顾性研究中，对患有高级别胶质瘤的参与者进行了生殖能力评估，这些参与者在2016年12月至2019年4月期间接受了连续三次标准护理检查。报告了5种健康组织类型的示踪剂动力学参数血浆体积分数和体积转移常数（Ktranss）的直方图统计的变异系数和重现性系数。对13名高级别胶质瘤参与者（平均年龄±标准差，61岁± 10岁; 9名女性）的图像进行了评价。在健康组织中，如果连续估计Ktranss，则该方案中位Ktranss的变异系数小于57%。对于大或低增强组织，中值Ktranss的最大再现系数估计为0.06 min-1，而对于较小或强增强组织，中值Ktranss的最大再现系数估计为0.48 min-1。全自动、稀疏采样的DCE MRI重建具有患者特异性血管输入功能，提供了高空间和时间分辨率以及全脑覆盖;在健康组织中，该方案估计的中值体积传递常数的最大再现性系数为0.06 min-1，低增强组织区域和小于0.48 min-1的最大再现系数在较小或更强增强组织区域中。在CC BY 4.0许可证下发布。在线补充材料可用于本文。另见Lenkinski在本期的社论。
Advances in sub-Nyquist–sampled dynamic contrast-enhanced (DCE) MRI enable monitoring of brain tumors with millimeter resolution and whole-brain coverage. Such undersampled quantitative methods need careful characterization regarding achievable test-retest reproducibility. To demonstrate a fully automated high-resolution whole-brain DCE MRI pipeline with 30-fold sparse undersampling and estimate its reproducibility on the basis of reference regions of stable tissue types during multiple posttreatment time points by using longitudinal clinical images of high-grade glioma. Two methods for sub-Nyquist–sampled DCE MRI were extended with automatic estimation of vascular input functions. Continuously acquired three-dimensional k-space data with ramped-up flip angles were partitioned to yield high-resolution, whole-brain tracer kinetic parameter maps with matched precontrast-agent T1 and M0 maps. Reproducibility was estimated in a retrospective study in participants with high-grade glioma, who underwent three consecutive standard-of-care examinations between December 2016 and April 2019. Coefficients of variation and reproducibility coefficients were reported for histogram statistics of the tracer kinetic parameters plasma volume fraction and volume transfer constant (Ktrans) on five healthy tissue types. The images from 13 participants (mean age ± standard deviation, 61 years ± 10; nine women) with high-grade glioma were evaluated. In healthy tissues, the protocol achieved a coefficient of variation less than 57% for median Ktrans, if Ktrans was estimated consecutively. The maximum reproducibility coefficient for median Ktrans was estimated to be at 0.06 min–1 for large or low-enhancing tissues and to be as high as 0.48 min–1 in smaller or strongly enhancing tissues. A fully automated, sparsely sampled DCE MRI reconstruction with patient-specific vascular input function offered high spatial and temporal resolution and whole-brain coverage; in healthy tissues, the protocol estimated median volume transfer constant with maximum reproducibility coefficient of 0.06 min–1 in large, low-enhancing tissue regions and maximum reproducibility coefficient of less than 0.48 min–1 in smaller or more strongly enhancing tissue regions. Published under a CC BY 4.0 license. Online supplemental material is available for this article. See also the editorial by Lenkinski in this issue.
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影响因子：
3.3
作者：
Feng, Li;Grimm, Robert;Block, Kai Tobias;Chandarana, Hersh;Kim, Sungheon;Xu, Jian;Axel, Leon;Sodickson, Daniel K.;Otazo, Ricardo
通讯作者：
Otazo, Ricardo
影响因子：
3.5
作者：
Cao, Yue
通讯作者：
Cao, Yue
影响因子：
3.3
作者：
Georgiou, Leonidas;Wilson, Daniel J.;Buckley, David L.
通讯作者：
Buckley, David L.
影响因子：
4.4
作者：
Bonekamp, David;Deike, Katerina;Heiland, Sabine
通讯作者：
Heiland, Sabine
影响因子：
15.9
作者：
Hutterer, Markus;Hattingen, Elke;Hau, Peter
通讯作者：
Hau, Peter