Dynamic brain network states in human generalized spike-wave discharges.
Dynamic brain network states in human generalized spike-wave discharges.
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DOI：
10.1093/brain/awy223
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发表时间：
2018-10-01
期刊：
影响因子：
--
通讯作者：
Richardson MP
中科院分区：
文献类型：
--
作者：
Tangwiriyasakul C;Perani S;Centeno M;Yaakub SN;Abela E;Carmichael DW;Richardson MP
特发性全身性癫痫（IGE）的广泛性尖峰波放电（GSW）似乎在脑电图上突然发作。然而，在啮齿动物模型中，GSW出现在进化的大脑网络状态中。Tangwiriyasakul等人利用EEG-fMRI发现，与啮齿类动物模型一样，人类IGE中的GSW发病是在进化的大脑网络状态中出现的。特发性全身性癫痫的全身性尖峰波放电通常被认为是突然发作和抵消的。然而，在啮齿动物模型中，放电是在大脑网络状态的动态进化过程中出现的，在放电前后持续几秒钟。在人类特发性广泛性癫痫中，同时进行的EEG和功能性MRI显示皮质区域在放电前可能是活跃的，并且放电周围的网络连接可能不正常。在这里，在人类特发性全身性癫痫中，我们研究了在大脑网络状态的动态进化过程中是否会出现全身性尖峰波放电。采用脑电图功能MRI对43例患者和34例健康对照者进行研究。我们从20例患者中获得95例出院病例。我们比较了出院患者、未出院患者和健康对照者的数据。仅在脑电图开始时和之后观察到放电时期MRI（血氧水平依赖）信号幅度的变化，涉及一系列顶叶和额叶皮质区，然后是丘脑（P < 0.01，在所有区域和测量时间点）。通过MRI信号相位同步检测90个脑区之间的功能连通性，我们发现在放电期间以及脑电偏移后20秒内，额叶、顶叶和枕叶皮层均存在显著连接（P < 0.01，所有连接和测量时间点均如此）。该网络在出院前16秒至10秒表现出显著的低同步性（在患者非出院时期该网络的同步性低于99%置信区间），然后在出院前2秒急剧上升至显著的高水平同步性。放电开始前一分钟，感觉运动网络出现显著连接。该网络还显示，与健康对照组相比，未出院患者的同步性升高（P = 0.004）。在放电前的6秒内，观察到该感觉运动网络的额外重要连接，涉及前额叶和楔前叶区域。在健康受试者中，重要的连接涉及后皮层网络。在出院的患者中，这个后神经网络在出院前一分钟表现出明显的低同步性。在未出院的患者中，该网络显示出与健康对照组相同的同步水平。我们的研究结果表明，持续的高感觉运动网络同步性，加上短暂的（至少1分钟）低后神经网络同步性，可能是一种易于发生全身性尖峰波放电的状态。我们的研究结果还表明，脑电图发作和相关的MRI信号幅度变化嵌入在放电事件前后相当长的一段时间内不断发展的大脑网络状态中。
Generalised spike-wave discharges (GSW) in idiopathic generalised epilepsy (IGE) appear to have abrupt onset on EEG. However, in rodent models, GSW emerge during evolving brain network states. Using EEG-fMRI, Tangwiriyasakul et al. reveal that GSW onset in human IGE, as in rodent models, emerges during evolving brain network states. Generalized spike-wave discharges in idiopathic generalized epilepsy are conventionally assumed to have abrupt onset and offset. However, in rodent models, discharges emerge during a dynamic evolution of brain network states, extending several seconds before and after the discharge. In human idiopathic generalized epilepsy, simultaneous EEG and functional MRI shows cortical regions may be active before discharges, and network connectivity around discharges may not be normal. Here, in human idiopathic generalized epilepsy, we investigated whether generalized spike-wave discharges emerge during a dynamic evolution of brain network states. Using EEG-functional MRI, we studied 43 patients and 34 healthy control subjects. We obtained 95 discharges from 20 patients. We compared data from patients with discharges with data from patients without discharges and healthy controls. Changes in MRI (blood oxygenation level-dependent) signal amplitude in discharge epochs were observed only at and after EEG onset, involving a sequence of parietal and frontal cortical regions then thalamus (P < 0.01, across all regions and measurement time points). Examining MRI signal phase synchrony as a measure of functional connectivity between each pair of 90 brain regions, we found significant connections (P < 0.01, across all connections and measurement time points) involving frontal, parietal and occipital cortex during discharges, and for 20 s after EEG offset. This network prominent during discharges showed significantly low synchrony (below 99% confidence interval for synchrony in this network in non-discharge epochs in patients) from 16 s to 10 s before discharges, then ramped up steeply to a significantly high level of synchrony 2 s before discharge onset. Significant connections were seen in a sensorimotor network in the minute before discharge onset. This network also showed elevated synchrony in patients without discharges compared to healthy controls (P = 0.004). During 6 s prior to discharges, additional significant connections to this sensorimotor network were observed, involving prefrontal and precuneus regions. In healthy subjects, significant connections involved a posterior cortical network. In patients with discharges, this posterior network showed significantly low synchrony during the minute prior to discharge onset. In patients without discharges, this network showed the same level of synchrony as in healthy controls. Our findings suggest persistently high sensorimotor network synchrony, coupled with transiently (at least 1 min) low posterior network synchrony, may be a state predisposing to generalized spike-wave discharge onset. Our findings also show that EEG onset and associated MRI signal amplitude change is embedded in a considerably longer period of evolving brain network states before and after discharge events.
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影响因子：
30.8
作者：
Helbig I;Mefford HC;Sharp AJ;Guipponi M;Fichera M;Franke A;Muhle H;de Kovel C;Baker C;von Spiczak S;Kron KL;Steinich I;Kleefuss-Lie AA;Leu C;Gaus V;Schmitz B;Klein KM;Reif PS;Rosenow F;Weber Y;Lerche H;Zimprich F;Urak L;Fuchs K;Feucht M;Genton P;Thomas P;Visscher F;de Haan GJ;Møller RS;Hjalgrim H;Luciano D;Wittig M;Nothnagel M;Elger CE;Nürnberg P;Romano C;Malafosse A;Koeleman BP;Lindhout D;Stephani U;Schreiber S;Eichler EE;Sander T
通讯作者：
Sander T
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
64.5
作者：
Klassen T;Davis C;Goldman A;Burgess D;Chen T;Wheeler D;McPherson J;Bourquin T;Lewis L;Villasana D;Morgan M;Muzny D;Gibbs R;Noebels J
通讯作者：
Noebels J
影响因子：
3.7
作者：
Gauvin L;Panisson A;Cattuto C
通讯作者：
Cattuto C
影响因子：
5.6
作者：
Blumenfeld, H
通讯作者：
Blumenfeld, H