Elucidation of host-pathogen protein-protein interactions to uncover mechanisms of host cell rewiring.
Elucidation of host-pathogen protein-protein interactions to uncover mechanisms of host cell rewiring.
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DOI：
10.1016/j.mib.2017.07.005
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发表时间：
2017-10
影响因子：
5.4
通讯作者：
Collins BC
中科院分区：
文献类型：
--
作者：
Nicod C;Banaei-Esfahani A;Collins BC
传染病是宿主和病原体之间分子交互作用的结果。这些交互作用部分由宿主-病原体蛋白质-蛋白质相互作用（HP-PPI）介导。HP-PPI在感染中起着至关重要的作用，因为它们可能会使平衡倾向于病原体的传播或清除。识别感染所需的病毒或细菌致病蛋白所靶向的宿主蛋白质可以深入了解其致病性的潜在分子机制，甚至可能选出药理干预靶点。在这里，我们回顾了现有的方法来研究HP-PPI，重点是最近的质谱法为基础的方法来破译细菌-人类传染病，并检查其相关性，揭示宿主细胞重新布线的病原体。
Infectious diseases are the result of molecular cross-talks between hosts and their pathogens. These cross-talks are in part mediated by Host-Pathogen Protein-Protein Interactions (HP-PPI). HP-PPI play crucial roles in infections, as they may tilt the balance either in favor of the pathogens’ spread or their clearance. The identification of host proteins targeted by viral or bacterial pathogenic proteins necessary for the infection can provide insights into their underlying molecular mechanisms of pathogenicity, and potentially even single out pharmacological intervention targets. Here, we review the available methods to study HP-PPI, with a focus on recent mass spectrometry based methods to decipher bacterial – human infectious diseases and examine their relevance in uncovering host cell rewiring by pathogens.
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