Antimicrobial resistance and management of invasive Salmonella disease.
Antimicrobial resistance and management of invasive Salmonella disease.
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DOI：
10.1016/j.vaccine.2015.03.102
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发表时间：
2015-06-19
期刊：
影响因子：
5.5
通讯作者：
Parry CM
中科院分区：
文献类型：
--
作者：
Kariuki S;Gordon MA;Feasey N;Parry CM
侵袭性沙门氏菌感染(伤寒和非伤寒)造成巨大的疾病负担，估计每年有近340万个病例和60多万人死亡，特别是在资源有限的环境中。侵袭性非伤寒沙门氏菌(INTS)感染在免疫抑制人群中尤其重要，特别是在撒哈拉以南非洲，导致5岁以下易受感染儿童死亡20%-30%。在这些环境中，很少或根本不存在抗菌素耐药性的常规监测，报告称NTS中50%-75%的多药耐药(MDR)很常见，包括NTS菌株也对氟喹诺酮类药物和第三代头孢菌素耐药。由伤寒沙门氏菌和甲型副伤寒沙门氏菌引起的伤寒(肠道)热仍然是亚洲和非洲许多地区的一个主要公共卫生问题。目前，在许多流行地区，超过三分之一的分离株是多药耐药，而过去十年来，对氟喹诺酮类药物敏感性或耐药性的降低，是治疗多药耐药病例的一个日益严重的问题。在资源有限的情况下，这种情况尤其令人担忧，因为剩下的为数不多的有效抗菌剂要么无法获得，要么过于昂贵，无法由普通公众或公共卫生服务负担得起。尽管谨慎使用有效的抗菌剂、改善卫生条件和发现新的抗菌剂可能会为侵袭性沙门氏菌感染的管理带来希望，但必须考虑其他干预措施，包括更广泛地使用世卫组织推荐的伤寒疫苗和加快新型INTS疫苗的试验。本审查的主要目的是描述关于抗菌素耐药侵袭性沙门氏菌感染的流行率和流行病学的现有数据，以及这如何影响这些感染的管理，特别是在流行的发展中国家。
Invasive Salmonella infections (typhoidal and non-typhoidal) cause a huge burden of illness estimated at nearly 3.4 million cases and over 600,000 deaths annually especially in resource-limited settings. Invasive non-typhoidal Salmonella (iNTS) infections are particularly important in immunosuppressed populations especially in sub-Saharan Africa, causing a mortality of 20–30% in vulnerable children below 5 years of age. In these settings, where routine surveillance for antimicrobial resistance is rare or non-existent, reports of 50–75% multidrug resistance (MDR) in NTS are common, including strains of NTS also resistant to flouroquinolones and 3rd generation cephalosporins. Typhoid (enteric) fever caused by Salmonella Typhi and Salmonella Paratyphi A remains a major public health problem in many parts of Asia and Africa. Currently over a third of isolates in many endemic areas are MDR, and diminished susceptibility or resistance to fluoroquinolones, the drugs of choice for MDR cases over the last decade is an increasing problem. The situation is particularly worrying in resource-limited settings where the few remaining effective antimicrobials are either unavailable or altogether too expensive to be afforded by either the general public or by public health services. Although the prudent use of effective antimicrobials, improved hygiene and sanitation and the discovery of new antimicrobial agents may offer hope for the management of invasive salmonella infections, it is essential to consider other interventions including the wider use of WHO recommended typhoid vaccines and the acceleration of trials for novel iNTS vaccines. The main objective of this review is to describe existing data on the prevalence and epidemiology of antimicrobial resistant invasive Salmonella infections and how this affects the management of these infections, especially in endemic developing countries.
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影响因子：
5.2
作者：
Gaind, R.;Paglietti, B.;Rubino, S.
通讯作者：
Rubino, S.
影响因子：
168.9
作者：
Feasey, Nicholas A.;Dougan, Gordon;Kingsley, Robert A.;Heyderman, Robert S.;Gordon, Melita A.
通讯作者：
Gordon, Melita A.
影响因子：
4.9
作者：
Chiou, Chien-Shun;Alam, Munirul;Wang, Pei-Jen
通讯作者：
Wang, Pei-Jen
影响因子：
4.9
作者：
Crump, John A.;Kretsinger, Katrina;Angulo, Frederick J.
通讯作者：
Angulo, Frederick J.
DOI：
10.1086/600299
发表时间：
2009-08-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Berkley JA;Bejon P;Mwangi T;Gwer S;Maitland K;Williams TN;Mohammed S;Osier F;Kinyanjui S;Fegan G;Lowe BS;English M;Peshu N;Marsh K;Newton CR
通讯作者：
Newton CR