Long-term depressive symptoms and midlife brain age.
Long-term depressive symptoms and midlife brain age.
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DOI：
10.1016/j.jad.2022.09.164
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发表时间：
2023-01-01
影响因子：
6.6
通讯作者：
Yaffe, Kristine
中科院分区：
文献类型：
--
作者：
Dintica, Christina S.;Habes, Mohamad;Erus, Guray;Simone, Tamar;Schreiner, Pamela;Yaffe, Kristine
有证据表明，抑郁症可能是老年人患痴呆症的一个风险因素，但抑郁症状与早期大脑健康之间的联系却鲜为人知。我们的目的是调查年轻到中年的长期抑郁症状与结构磁共振得出的脑年龄测量之间的联系。从青年冠状动脉风险发展研究中，我们确定了649名参与者(基线年龄为23-36岁)，进行了脑MRI和认知测试。用流行病学研究中心抑郁量表(CES-D)在25年间6次测量长期抑郁症状，并以时间加权平均值(TWA)进行分析。脑年龄是通过先前验证的高维神经成像模式分析得出的，量化了年龄相关性萎缩的个体差异。抑郁症状升高的定义为CES-D≥16。采用线性回归方法检验抑郁症状、脑老化和认知之间的关系。25年TWA抑郁症状的标准差(5分)每增加一次与一年的大脑年龄相关(β：1.14，95%可信区间[CI]：0.57至1.71)。TWA抑郁症状升高的参与者平均脑年龄较大3年(β：2.75，95%CI：0.43至5.08)。此外，抑郁症状的增加与中年认知功能低下的几率更高(OR：3.30，95%CI：1.37~7.97)。一次评估大脑年龄，限制了我们评估抑郁症状和大脑老化的暂时性的能力。成年早期抑郁症状的增加可能对大脑健康有影响，早在中年就有。
Evidence suggests that depression may be a risk factor for dementia in older adults, but the link between depressive symptoms and brain health earlier in life is less understood. Our aim was to investigate the association between long-term depressive symptoms in young to mid-adulthood and a measure of brain age derived from structural MRI. From the Coronary Artery Risk Development in Young Adults study, we identified 649 participants (age 23–36 at baseline) with brain MRI and cognitive testing. Long-term depressive symptoms were measured with the Center for Epidemiological Studies Depression scale (CES–D) six times across 25 years and analyzed as time-weighted averages (TWA). Brain age was derived using previously validated high dimensional neuroimaging pattern analysis, quantifying individual differences in age-related atrophy. Elevated depressive symptoms were defined as CES-D ≥16. Linear regression was used to test the association between TWA depressive symptoms, brain aging, and cognition. Each standard deviation (5-points) increment in TWA depression symptoms over 25 years was associated with one-year greater brain age (β: 1.14, 95 % confidence interval [CI]: 0.57 to 1.71). Participants with elevated TWA depressive symptoms had on average a 3-year greater brain age (β: 2.75, 95 % CI: 0.43 to 5.08). Moreover, elevated depressive symptoms were associated with higher odds of poor cognitive function in midlife (OR: 3.30, 95 % CI: 1.37 to 7.97). Brain age was assessed at one time, limiting our ability to evaluate the temporality of depressive symptoms and brain aging. Elevated depressive symptoms in early adulthood may have implications for brain health as early as in midlife.
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DOI：
10.1016/j.bbi.2018.07.012
发表时间：
2018-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Fonken LK;Frank MG;Gaudet AD;Maier SF
通讯作者：
Maier SF
影响因子：
6.8
作者：
Han LKM;Schnack HG;Brouwer RM;Veltman DJ;van der Wee NJA;van Tol MJ;Aghajani M;Penninx BWJH
通讯作者：
Penninx BWJH
影响因子：
9.9
作者：
Al Hazzouri, Adina Zeki;Caunca, Michelle R.;Wright, Clinton B.
通讯作者：
Wright, Clinton B.
影响因子：
6.3
作者：
McEvoy CT;Guyer H;Langa KM;Yaffe K
通讯作者：
Yaffe K
影响因子：
4.8
作者：
Doshi, Jimit;Erus, Guray;Ou, Yangming;Gaonkar, Bilwaj;Davatzikos, Christos
通讯作者：
Davatzikos, Christos