Contributing factors to advanced brain aging in depression and anxiety disorders.
Contributing factors to advanced brain aging in depression and anxiety disorders.
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DOI：
10.1038/s41398-021-01524-2
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发表时间：
2021-07-21
影响因子：
6.8
通讯作者：
Penninx BWJH
中科院分区：
文献类型：
--
作者：
Han LKM;Schnack HG;Brouwer RM;Veltman DJ;van der Wee NJA;van Tol MJ;Aghajani M;Penninx BWJH
抑郁症和焦虑症是常见的，往往是共病的心理健康障碍，代表了与衰老有关的疾病的危险因素。研究表明，重度抑郁症（MDD）患者的大脑老化更为严重。在这里，我们通过调查MDD、焦虑症或两者兼而有之患者的多变量脑老化来扩展先前的工作，并检查哪些因素有助于大脑变老。来自荷兰抑郁和焦虑研究的18-57岁的成年人接受了结构MRI。应用基于来自ENIGMA联盟的>2000个样本的预训练的脑年龄预测模型，以获得65名对照和220名当前患有MDD和/或焦虑症的患者的脑预测年龄差异（脑PAD，预测脑年龄减去实际年龄）。脑PAD估计值与临床、躯体、生活方式和生物学因素相关。校正抗抑郁药使用后，与对照组相比，MDD患者（+2.78岁，Cohen's d = 0.25，95%CI −0.10-0.60）和焦虑患者（+2.91岁，Cohen's d = 0.27，95%CI −0.08-0.61）的脑PAD显著更高。与生活方式或生物应激系统没有显著关联。多变量模型表明，躯体抑郁症状严重程度较高（平均总分每增加一个单位，B = 4.21年）和抗抑郁药使用（-2.53年）对脑PAD的独特贡献。重度抑郁症和焦虑症患者的晚期脑老化与躯体抑郁症密切相关。我们还提供了临床相关证据，表明抗抑郁药对脑PAD指标具有潜在的神经保护作用，需要在未来的研究中进行随访。
Depression and anxiety are common and often comorbid mental health disorders that represent risk factors for aging-related conditions. Brain aging has shown to be more advanced in patients with major depressive disorder (MDD). Here, we extend prior work by investigating multivariate brain aging in patients with MDD, anxiety disorders, or both, and examine which factors contribute to older-appearing brains. Adults aged 18–57 years from the Netherlands Study of Depression and Anxiety underwent structural MRI. A pretrained brain-age prediction model based on >2000 samples from the ENIGMA consortium was applied to obtain brain-predicted age differences (brain PAD, predicted brain age minus chronological age) in 65 controls and 220 patients with current MDD and/or anxiety. Brain-PAD estimates were associated with clinical, somatic, lifestyle, and biological factors. After correcting for antidepressant use, brain PAD was significantly higher in MDD (+2.78 years, Cohen’s d = 0.25, 95% CI −0.10-0.60) and anxiety patients (+2.91 years, Cohen’s d = 0.27, 95% CI −0.08-0.61), compared with controls. There were no significant associations with lifestyle or biological stress systems. A multivariable model indicated unique contributions of higher severity of somatic depression symptoms (b = 4.21 years per unit increase on average sum score) and antidepressant use (−2.53 years) to brain PAD. Advanced brain aging in patients with MDD and anxiety was most strongly associated with somatic depressive symptomatology. We also present clinically relevant evidence for a potential neuroprotective antidepressant effect on the brain-PAD metric that requires follow-up in future research.
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DOI：
10.1176/appi.ajp.2018.17060595
发表时间：
2018-08-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Han LKM;Aghajani M;Clark SL;Chan RF;Hattab MW;Shabalin AA;Zhao M;Kumar G;Xie LY;Jansen R;Milaneschi Y;Dean B;Aberg KA;van den Oord EJCG;Penninx BWJH
通讯作者：
Penninx BWJH
影响因子：
16.2
作者：
Esposito K;Chiodini P;Colao A;Lenzi A;Giugliano D
通讯作者：
Giugliano D
影响因子：
11
作者：
Felger JC;Haroon E;Patel TA;Goldsmith DR;Wommack EC;Woolwine BJ;Le NA;Feinberg R;Tansey MG;Miller AH
通讯作者：
Miller AH
影响因子：
4.2
作者：
Bas-Hoogendam, Janna Marie;van Steenbergen, Henk;van der Wee, Nic J. A.
通讯作者：
van der Wee, Nic J. A.
影响因子：
4.8
作者：
Franke K;Gaser C;Manor B;Novak V
通讯作者：
Novak V