Compact DD generator-based neutron activation analysis (NAA) system to determine fluorine in human bone in vivo: a feasibility study.
Compact DD generator-based neutron activation analysis (NAA) system to determine fluorine in human bone in vivo: a feasibility study.
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基于紧凑的DD发生器的中子激活分析（NAA）系统，以确定体内人骨中的氟：一项可行性研究。
DOI：
10.1088/0967-3334/36/10/2057
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发表时间：
2015-10
影响因子：
3.2
通讯作者：
Nie LH
中科院分区：
文献类型：
--
作者：
Mostafaei F;Blake SP;Liu Y;Sowers DA;Nie LH
氟（F）是否对人体健康有害的问题多年来一直存在争议。大部分的讨论集中在已知的好处和牙科护理和问题，氟在骨结构造成的高剂量。因此，拥有监测人体中氟浓度的手段作为直接评估暴露的方法是有利的。氟在骨骼中积累，使骨骼成为评估长期累积暴露于氟的有用生物标志物。这项研究提出了一种非侵入性的方法监测人体骨骼中的F的发展工作。这项工作是基于在体中子活化分析（IVNAA）技术。使用紧凑型氘-氘（DD）发生器产生中子。设计并制造了用于人手照射的减速器/反射器/屏蔽组件。使用HPGe探测器测量通过19 F（n，γ）20 F反应发射的γ射线。本研究的目的是（i）寻找使用DD系统测定人骨中F的可行性，（ii）估计F的最小检测限（MDL），以及（iii）使用蒙特卡罗N粒子扩展（MCNPX）代码优化系统以提高系统的MDL。在实验中，在7 × 108 ns −1的中子通量和优化的辐照、衰变和测量时间方案下，发现F MDL为0.54 g。在相同的辐照和探测参数下，实验得到的F计数值与MCNPX模拟结果接近。手的等效剂量和全身的有效剂量分别为0.9mSv和0.33 μSv。基于这些结果，它是可行的，以开发一个紧凑的DD发生器为基础的IVNAA系统，以测量骨氟在人群中具有中度至高度的F暴露。
The subject of whether fluorine (F) is detrimental to human health has been controversial for many years. Much of the discussion focuses on the known benefits and detriments to dental care and problems that F causes in bone structure at high doses. It is therefore advantageous to have the means to monitor F concentrations in the human body as a method to directly assess exposure. F accumulates in the skeleton making bone a useful biomarker to assess long term cumulative exposure to F. This study presents work in the development of a non-invasive method for the monitoring of F in human bone. The work was based on the technique of in vivo neutron activation analysis (IVNAA). A compact deuterium-deuterium (DD) generator was used to produce neutrons. A moderator/reflector/shielding assembly was designed and built for human hand irradiation. The gamma rays emitted through the 19F(n,γ)20F reaction were measured using a HPGe detector. This study was undertaken to (i) find the feasibility of using DD system to determine F in human bone, (ii) estimate the F minimum detection limit (MDL), and (iii) optimize the system using the Monte Carlo N-Particle eXtended (MCNPX) code in order to improve the MDL of the system. The F MDL was found to be 0.54 g experimentally with a neutron flux of 7 × 108 n s−1 and an optimized irradiation, decay, and measurement time scheme. The numbers of F counts from the experiment were found to be close to the (MCNPX) simulation results with the same irradiation and detection parameters. The equivalent dose to the irradiated hand and the effective dose to the whole body were found to be 0.9 mSv and 0.33 μSv, respectively. Based on these results, it is feasible to develop a compact DD generator based IVNAA system to measure bone F in a population with moderate to high F exposure.
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影响因子：
7.6
作者：
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通讯作者：
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作者：
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作者：
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