Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults.
Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults.
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DOI：
10.1080/13854040802360558
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Chui H
中科院分区：
文献类型：
--
作者：
Tomaszewski Farias S;Cahn-Weiner DA;Harvey DJ;Reed BR;Mungas D;Kramer JH;Chui H
日常功能受损是痴呆症的诊断标准，也是医疗保健利用和照顾者负担的决定因素。尽管许多先前的研究已经证明了认知（特别是执行功能和记忆）与老年人日常功能之间的横截面关系，但对这些领域之间的纵向关系知之甚少。本研究探讨了情景记忆（MEM）和执行功能（EXEC）的纵向变化与日常功能变化之间的关系。参与者是一个认知异质组的100名老年人，包括那些正常的认知，以及那些有轻度认知障碍和痴呆症。他们平均被跟踪了五年。随机效应模型显示，MEM和EXEC的变化与被调查者评定的工具性日常生活活动（IADL）的变化率独立相关，即使在控制了年龄、教育和性别之后。研究结果表明，随着时间的推移，MEM和EXEC的下降对老年人日常生活能力的下降做出了独特和独立的贡献。
Impaired everyday function is a diagnostic criterion for dementia, and a determinant of healthcare utilization and caregiver burden. Although many previous studies have demonstrated a cross-sectional relationships between cognition (particularly executive functions and memory) and everyday function in older adults, very little is known about longitudinal relationships between these domains. This study examined the association between longitudinal change in episodic memory (MEM) and executive functioning (EXEC) and change in everyday function. Participants were a cognitively heterogeneous group of 100 elderly persons including those with normal cognition, as well as those with mild cognitive impairment and dementia. They were followed for an average of five years. Random effects modeling showed that change in both MEM and EXEC were independently associated with rate of change in informant-rated instrumental activities of daily living (IADLs), even after controlling for age, education, and gender. Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults’ ability to function in daily life.
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DOI：
10.1080/01688639008400980
发表时间：
1990-03-01
影响因子：
2.2
作者：
DEBETTIGNIES, BH;MAHURIN, RK;PIROZZOLO, FJ
通讯作者：
PIROZZOLO, FJ
DOI：
10.1111/j.1532-5415.1998.tb01075.x
发表时间：
1998-05-01
影响因子：
6.3
作者：
Grigsby, J;Kaye, K;Hamman, RF
通讯作者：
Hamman, RF
DOI：
10.1017/s1355617704103020
发表时间：
2004-05-01
影响因子：
2.6
作者：
Farias, ST;Mungas, D;Jagust, WJ
通讯作者：
Jagust, WJ
影响因子：
4
作者：
Boyle, PA;Cohen, RA;Gordon, N
通讯作者：
Gordon, N
影响因子：
8.3
作者：
Carey, Catherine L.;Kramer, Joel H.;Chui, Helena C.
通讯作者：
Chui, Helena C.