A common strategy for initiating the transition from proliferation to quiescence.
A common strategy for initiating the transition from proliferation to quiescence.
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DOI：
10.1007/s00294-016-0640-0
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发表时间：
2017-05
期刊：
影响因子：
2.5
通讯作者：
Breeden L
中科院分区：
文献类型：
--
作者：
Miles S;Breeden L
多细胞生物体的发育、组织更新和长期存活取决于干细胞的持续存在，所述干细胞是静止的，但保留重新进入细胞周期以自我更新的能力，或产生可以分化和重新填充组织的后代的能力。这些细胞从静止状态释放的失调，或阻止它们进入静止状态，导致不受控制的增殖和癌症。相反，失去静止细胞或它们无法重新进入细胞分裂，会破坏器官发育并阻止组织再生和修复。了解静止状态以及细胞如何控制这种状态的转换是至关重要的。对G1期停滞在向静止过渡期间的机制的调查继续确定酵母和哺乳动物用于调节这种过渡的策略之间的惊人相似之处。当细胞进入稳定但可逆的停滞时，负责促进S期的G1/S基因必须被抑制。从酵母到人类，这一过程涉及在其启动子上形成静止特异性复合物。在高等细胞中，这些所谓的E2 F4/DP/RBL/MuvB的DREAM复合物招募高度保守的组蛋白脱乙酰酶HDAC 1，这导致局部组蛋白脱乙酰化和S期促进转录物的抑制。静止的酵母细胞也显示出普遍的组蛋白去乙酰化的HDAC 1对应物Rpd 3。此外，这些细胞含有G1/S基因的静止特异性调节因子：Msa 1和Msa 2，它们可以被认为是DREAM复合物的酵母等同物的组成部分。尽管缺乏物理相似性，但用于实现可逆过渡到静止的目标和策略是高度保守的。这激发了在简单的模式生物：芽殖酵母中对这一过程进行详细研究。
Development, tissue renewal and long term survival of multi-cellular organisms is dependent upon the persistence of stem cells that are quiescent, but retain the capacity to re-enter the cell cycle to self-renew, or to produce progeny that can differentiate and re-populate the tissue. Deregulated release of these cells from the quiescent state, or preventing them from entering quiescence, results in uncontrolled proliferation and cancer. Conversely, loss of quiescent cells, or their failure to re-enter cell division, disrupts organ development and prevents tissue regeneration and repair. Understanding the quiescent state and how cells control the transitions in and out of this state is of fundamental importance. Investigations into the mechanics of G1 arrest during the transition to quiescence continue to identify striking parallels between the strategies used by yeast and mammals to regulate this transition. When cells commit to a stable but reversible arrest, the G1/S genes responsible for promoting S phase must be inhibited. This process, from yeast to humans, involves the formation of quiescence-specific complexes on their promoters. In higher cells these so-called DREAM complexes of E2F4/DP/RBL/MuvB recruit the highly conserved histone deacetylase HDAC1, which leads to local histone deacetylation and repression of S phase-promoting transcripts. Quiescent yeast cells also show pervasive histone deacetylation by the HDAC1 counterpart Rpd3. In addition, these cells contain quiescence-specific regulators of G1/S genes: Msa1 and Msa2, which can be considered components of the yeast equivalent of the DREAM complex. Despite a lack of physical similarities, the goals and the strategies used to achieve a reversible transition to quiescence are highly conserved. This motivates a detailed study of this process in the simple model organism: budding yeast.
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影响因子：
5.3
作者：
Alland, L;David, G;DePinho, RA
通讯作者：
DePinho, RA
影响因子：
16
作者：
Ceol, CJ;Horvitz, HR
通讯作者：
Horvitz, HR
影响因子：
3.3
作者：
Chen, Ying-Chou;Kenworthy, Jessica;Weinreich, Michael
通讯作者：
Weinreich, Michael
DOI：
10.1083/jcb.200604072
发表时间：
2006-07-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Allen C;Büttner S;Aragon AD;Thomas JA;Meirelles O;Jaetao JE;Benn D;Ruby SW;Veenhuis M;Madeo F;Werner-Washburne M
通讯作者：
Werner-Washburne M
影响因子：
5.3
作者：
CROSS, FR
通讯作者：
CROSS, FR