Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
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缺乏CD157/BST1基因的小鼠的焦虑和抑郁症行为，这是帕金森氏病的危险因素。
DOI：
10.3389/fnbeh.2014.00133
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发表时间：
2014
影响因子：
3
通讯作者：
Higashida H
中科院分区：
文献类型：
--
作者：
Lopatina O;Yoshihara T;Nishimura T;Zhong J;Akther S;Fakhrul AA;Liang M;Higashida C;Sumi K;Furuhara K;Inahata Y;Huang JJ;Koizumi K;Yokoyama S;Tsuji T;Petugina Y;Sumarokov A;Salmina AB;Hashida K;Kitao Y;Hori O;Asano M;Kitamura Y;Kozaka T;Shiba K;Zhong F;Xie MJ;Sato M;Ishihara K;Higashida H
CD157，被称为骨髓基质细胞抗原-1，是一种糖基磷脂酰肌醇锚定的adp -核糖基环化酶，支持b淋巴细胞和造血或肠道干细胞的存活和功能。虽然CD157/Bst1是帕金森病（PD）的危险位点，但关于CD157在神经系统中的功能及其对PD进展的贡献知之甚少。在这里，我们发现在年龄相关的行为影响较小的年轻敲除（CD157−/−）雄性小鼠中没有观察到明显的运动功能障碍。与野生型小鼠相比，CD157−/−小鼠表现出焦虑相关和抑郁样行为。通过抗精神病药物和催产素的治疗，这些行为得以恢复。CD157在杏仁核中的表达较弱，CD157−/−小鼠杏仁核中的c-Fos免疫反应性不如野生型小鼠明显。这些结果首次证明CD157作为一种神经调节剂发挥作用，并提示在PD的运动前症状中发挥潜在作用。
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157−/−) male mice under less aging-related effects on behaviors. CD157−/− mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157−/− mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.
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影响因子：
3.5
作者：
Churchland, Patricia S.;Winkielman, Piotr
通讯作者：
Winkielman, Piotr
影响因子：
3
作者：
Campos FL;Carvalho MM;Cristovão AC;Je G;Baltazar G;Salgado AJ;Kim YS;Sousa N
通讯作者：
Sousa N
影响因子：
3.5
作者：
HIRATA, Y;KIMURA, N;HIRANO, T
通讯作者：
HIRANO, T
影响因子：
20.3
作者：
Funaro, A;Ortolan, E;Malavasi, F
通讯作者：
Malavasi, F
影响因子：
3.2
作者：
Ferrero, E;Saccucci, F;Malavasi, F
通讯作者：
Malavasi, F