Hippocampal network activity is transiently altered by induction of long-term potentiation in the dentate gyrus of freely behaving rats.
Hippocampal network activity is transiently altered by induction of long-term potentiation in the dentate gyrus of freely behaving rats.
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海马网络活性通过诱导自由行为大鼠的齿状回的长期增强而瞬时改变。
DOI：
10.3389/neuro.08.007.2007
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发表时间：
2007
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
海马神经元网络中的振荡活动在感觉编码、认知功能和突触可塑性中的作用已被提出。在海马区，θ(5-10 赫兹)和伽马(30-100 赫兹)振荡可能为信息的时间编码提供了一种机制，也为记忆痕迹的形成和提取提供了基础。突触传递的长时程增强(LTP)是突触信息存储的一种候选细胞模型，通常由传入通路的高频强直(HFT)诱导。考虑到振荡活动在信息加工中的作用，在高频电刺激期间和/或高频电刺激后不久，海马区的网络活动可能会发生动态变化。节律性活动的这些变化可能决定或至少有助于成功的增强，并总体上有助于记忆的形成。我们发现，短时程增强(STP)和LTP以及LTP-Failure具有不同的theta和Gamma频率变化曲线。突触传递的增强与高频辐射后约300 秒的相对theta功率和theta周期平均幅度的显着增加有关。在发生LTP或STP而不是增强失败的情况下，这种促进theta的过程伴随着伽马功率的瞬时增加和单个theta周期内伽马振荡的平均幅度的增加。我们的数据支持，这些参数中特定的、相关的变化与成功的突触增强有关。这些发现表明，与LTP诱导相关的theta-Gamma活动的变化可能使突触信息存储在海马区。
A role for oscillatory activity in hippocampal neuronal networks has been proposed in sensory encoding, cognitive functions and synaptic plasticity. In the hippocampus, theta (5–10 Hz) and gamma (30–100 Hz) oscillations may provide a mechanism for temporal encoding of information, and the basis for formation and retrieval of memory traces. Long-term potentiation (LTP) of synaptic transmission, a candidate cellular model of synaptic information storage, is typically induced by high-frequency tetanisation (HFT) of afferent pathways. Taking into account the role of oscillatory activity in the processing of information, dynamic changes may occur in hippocampal network activity in the period during HFT and/or soon after it. These changes in rhythmic activity may determine or, at least, contribute to successful potentiation and, in general, to formation of memory. We have found that short-term potentiation (STP) and LTP as well LTP-failure are characterised with different profiles of changes in theta and gamma frequencies. Potentiation of synaptic transmission was associated with a significant increase in the relative theta power and mean amplitude of theta cycles in the period encompassing 300 seconds after HFT. Where LTP or STP, but not failure of potentiation, occurred, this facilitation of theta was accompanied by transient increases in gamma power and in the mean amplitude of gamma oscillations within a single theta cycle. Our data support that specific, correlated changes in these parameters are associated with successful synaptic potentiation. These findings suggest that changes in theta-gamma activity associated with induction of LTP may enable synaptic information storage in the hippocampus.
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影响因子：
2.9
作者：
Hasselmo, ME;Bodelón, C;Wyble, BP
通讯作者：
Wyble, BP
影响因子：
3.5
作者：
Buzsáki, G
通讯作者：
Buzsáki, G
影响因子：
2.9
作者：
ABRAHAM, WC;MCNAUGHTON, N
通讯作者：
MCNAUGHTON, N
影响因子：
56.9
作者：
FREY, U;HUANG, YY;KANDEL, ER
通讯作者：
KANDEL, ER
影响因子：
25
作者：
Fries, P;Neuenschwander, S;Singer, W
通讯作者：
Singer, W