The 10 bp duplication insertion/deletion in the promoter region within paired box 7 gene is associated with growth traits in cattle
The 10 bp duplication insertion/deletion in the promoter region within paired box 7 gene is associated with growth traits in cattle
复制标题
配对框 7 基因内启动子区域的 10 bp 重复插入/缺失与牛的生长性状相关
DOI：
10.5194/aab-59-469-2016
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发表时间：
2016-11
影响因子：
1.8
通讯作者：
Lan Xianyong
中科院分区：
文献类型：
--
作者：
Jin Yunyun;Cai Hanfang;Liu Jiming;Lin Fengpeng;Qi Xinglei;Bai Yueyu;Lei Chuzhao;Chen Hong;Lan Xianyong
Paired box 7（Pax 7）基因是Paired box基因家族的成员之一，在动物的生长发育、肌肉发育，尤其是细胞增殖和自我更新中起着重要作用。本研究旨在检测牛Pax 7基因启动子区10 bp重复插入/缺失（indel）及其与生长性状的关系。本研究共对我国5个牛品种的718头个体进行了抽样检测。在这些牛种中均发现了10 bp的重复插入/缺失，并存在3种基因型：II（插入/插入）、ID（插入/缺失）和DD（缺失/缺失）。该插入缺失与夏南牛体重、晋江牛体高和皮南牛臀宽显著相关。结果表明，在5个品种中，II基因型个体的表型性状优于其他基因型个体。这些结果表明，牛Pax 7基因内的10 bp重复indel可以作为一个有效的DNA分子标记，为今后肉牛的标记辅助选择（MAS）提供有价值的理论依据。
Paired box 7 (Pax7) gene, a member of the paired box gene family, plays a critical role in animal growth and muscle development, especially in cell proliferation and self-renewal. The aim of this study was to detect the 10 base pair (bp) duplication insertion/deletion (indel) in the promoter region within the bovinePax7gene as well as its association with growth traits. Herein, a total of 718 individuals from five Chinese cattle breeds were sampled and detected. The 10 bp duplication indel was found in these cattle breeds and there were three genotypes: II (insertion/insertion), ID (insertion/deletion), and DD (deletion/deletion). Moreover, this indel was significantly associated with the body weight in Xianan cattle (), the body height in Jinjiang cattle (), and the hip width in Pi'nan cattle (). Consistently, the individuals with II genotype showed better phenotypic traits than those with the other genotypes in these five breeds. These findings suggest that the 10 bp duplication indel within the bovinePax7gene could be considered as an effective DNA molecular marker that provides valuable theoretical basis for marker-assisted selection (MAS) in beef cattle in the future.
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影响因子：
2.5
作者：
Galli, Lisa M.;Knight, Sara R.;Barnes, Tiffany L.;Doak, Allison K.;Kadzik, Rachel S.;Burrus, Laura W.
通讯作者：
Burrus, Laura W.
影响因子：
2.3
作者：
Qing Yang;Sihuan Zhang;Liangliang Liu;Xiu-Kai Cao;C. Lei;Xinglei Qi;Fengpeng Lin;Weidong Qu;Xingshan Qi;Jiming Liu;Rongmin Wang;Hong Chen;X. Lan
通讯作者：
Qing Yang;Sihuan Zhang;Liangliang Liu;Xiu-Kai Cao;C. Lei;Xinglei Qi;Fengpeng Lin;Weidong Qu;Xingshan Qi;Jiming Liu;Rongmin Wang;Hong Chen;X. Lan
影响因子：
2.6
作者：
JOSTES, B;WALTHER, C;GRUSS, P
通讯作者：
GRUSS, P
影响因子：
3.1
作者：
Yao Xu;Yang Zhou;Ning Wang;X. Lan;Chunlei Zhang;C. Lei;Hong Chen
通讯作者：
Yao Xu;Yang Zhou;Ning Wang;X. Lan;Chunlei Zhang;C. Lei;Hong Chen
影响因子：
3.5
作者：
Dang, Yonglong;Li, Mingxun;Chen, Hong
通讯作者：
Chen, Hong