Aberrant paralimbic gray matter in incarcerated male adolescents with psychopathic traits.

Aberrant paralimbic gray matter in incarcerated male adolescents with psychopathic traits.
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DOI:
10.1016/j.jaac.2012.10.013
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发表时间:
2013-01
影响因子:
13.3
通讯作者:
Kiehl KA
Kiehl KA
中科院分区:
医学1区
文献类型:
--
作者:
Ermer E;Cope LM;Nyalakanti PK;Calhoun VD;Kiehl KA

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为了调查最高安全级别的被监禁男性青少年的大脑结构和精神病特征之间的关系:在被监禁的成年男性中观察到的旁边缘和边缘区域的脑容量与精神病特征之间的关联是否扩展到被监禁男性青少年的独立样本?使用基于体素的形态测定法 (VBM) 对最高安全级别的监禁男性青少年 (N=218) 进行区域灰质体积 (GMV) 的结构磁共振成像 (MRI) 研究,并使用 Hare 精神病检查表 - 青年版 (PCL-YV) 评估其精神病特征。所有分析都控制了年龄、物质使用和大脑大小的影响。与假设和成人文献一致,精神变态特征与弥漫性旁边缘区域(包括眶额皮层、双侧颞极和后扣带皮层)的区域 GMV 降低有关。这些结果强化了这样的解释:旁边缘区域是理解与精神病特征相关的神经功能障碍的核心,并且精神病最好被概念化为神经发育障碍。
To investigate the relationship between brain structure and psychopathic traits in maximum-security incarcerated male adolescents: Do the associations between brain volumes in paralimbic and limbic regions and psychopathic traits observed in incarcerated adult men extend to an independent sample of incarcerated male adolescents? A structural magnetic resonance imaging (MRI) study of regional gray matter volumes (GMV) by using voxel-based morphometry (VBM) in maximum-security incarcerated male adolescents (N=218) assessed for psychopathic traits using the Hare Psychopathy Checklist–Youth Version (PCL-YV). All analyses controlled for effects of age, substance use, and brain size. Consistent with hypotheses and the adult literature, psychopathic traits were associated with decreased regional GMV in diffuse paralimbic regions, including orbitofrontal cortex, bilateral temporal poles, and posterior cingulate cortex. These results strengthen the interpretation that paralimbic regions are central for understanding neural dysfunction associated with psychopathic traits and that psychopathy is best conceptualized as a neurodevelopmental disorder.
DOI: 10.1037/a0026371
发表时间: 2012-08
影响因子: 4.6
作者:
Ermer, Elsa;Cope, Lora M.;Nyalakanti, Prashanth K.;Calhoun, Vince D.;Kiehl, Kent A.
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