Convergent gustatory and viscerosensory processing in the human dorsal mid-insula.
Convergent gustatory and viscerosensory processing in the human dorsal mid-insula.
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人背侧互联网中的收敛性和内脏感应。
DOI：
10.1002/hbm.23510
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发表时间：
2017-04
影响因子：
4.8
通讯作者：
Kyle Simmons W
中科院分区：
文献类型：
--
作者：
Avery JA;Gotts SJ;Kerr KL;Burrows K;Ingeholm JE;Bodurka J;Martin A;Kyle Simmons W
摄食行为的动态平衡调节要求有机体能够将来自其内部环境的信息(包括关于身体当前能量需求的外周内脏信号)与来自外部环境的信息(如富含能量的食物刺激的适口性)整合在一起。脑岛是大脑的主要感觉皮质，既代表来自身体的内脏信号，也代表来自嘴巴和舌头的味觉信号，可能是这种整合发生的候选区域。然而，到目前为止，还不清楚来自这两个自我恒定的关键能力的信息是仅仅在人类岛上共同呈现，还是实际上在那里整合。最近的功能神经成像证据表明，人类中岛背侧存在内脏内感和味觉的共同底物，这表明一种模型，即单个神经元群体可能整合内脏感觉和味觉信号。为了测试这一模型，我们使用fMRI适应性来确定在重复的内感试验后表现出重复抑制的岛区是否也会对随后的味觉刺激表现出适应性反应。岛叶的多个中部和前部区域表现出对内感试验的适应，但只有岛背中部区域在内感试验后表现出适应性的味觉反应。人类脑岛神经元内这种味觉-感觉间会聚的发现支持了一种迄今未见文献记载的神经通路的存在，即来自外周的内脏信号调节参与摄食行为的大脑区域的活动。
The homeostatic regulation of feeding behavior requires an organism to be able to integrate information from its internal environment, including peripheral visceral signals about the body’s current energy needs, with information from its external environment, such as the palatability of energy-rich food stimuli. The insula, which serves as the brain’s primary sensory cortex for representing both visceral signals from the body and taste signals from the mouth and tongue, is a likely candidate region in which this integration might occur. However, to date it has been unclear whether information from these two homeostatically critical faculties is merely co-represented in the human insula, or actually integrated there. Recent functional neuroimaging evidence of a common substrate for visceral interoception and taste perception within the human dorsal mid-insula suggests a model whereby a single population of neurons may integrate viscerosensory and gustatory signals. To test this model, we used fMRI-Adaptation to identify whether insula regions that exhibit repetition suppression following repeated interoception trials would then also exhibit adapted responses to subsequent gustatory stimuli. Multiple mid and anterior regions of the insula exhibited adaptation to interoceptive trials specifically, but only the dorsal mid-insula regions exhibited an adapted gustatory response following interoception. The discovery of this gustatory-interoceptive convergence within the neurons of the human insula supports the existence of a heretofore-undocumented neural pathway by which visceral signals from the periphery modulate the activity of brain regions involved in feeding behavior.
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影响因子：
3
作者：
Oliveira-Maia AJ;de Araujo IE;Monteiro C;Workman V;Galhardo V;Nicolelis MA
通讯作者：
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影响因子：
2
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通讯作者：
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影响因子：
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作者：
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