Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.

Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.
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DOI:
10.1007/s40506-020-00237-2
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发表时间:
2020
影响因子:
2
通讯作者:
de Alwis R
de Alwis R
中科院分区:
其他
文献类型:
--
作者:
Bifani AM;Ong EZ;de Alwis R

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在世纪之交,黄热病(YF)被认为是最危险的传染病,病死率高。随后,大规模疫苗接种运动加上广泛消灭YF蚊媒,大大减少了YF病例,并减少了非洲和南美洲热带和亚热带森林地区的疫情。然而,最近(2016年)在安哥拉、刚果民主共和国(DRC)和巴西东南部发生的大规模疫情(这些地区以前被划分为低风险地区),突显了流行病学迅速变化和黄热病病毒(YFV)可能重新出现的可能性。此外,亚洲首次输入YFV,凸显了对YFV成为全球威胁的潜在担忧。在这篇综述中,我们描述了不断变化的流行病学的YF爆发,并强调使用公共卫生政策,治疗和疫苗接种的工具,以帮助消除未来的YFV爆发。
At the turn of the nineteenth century, yellow fever (YF) was considered the most dangerous infectious disease with high case fatality. Subsequent, mass vaccination campaigns coupled with widespread elimination of the YF mosquito vector significantly decreased YF cases and reduced outbreaks to the tropical and subtropical forested regions of Africa and South America. However, recent (2016) large outbreaks in Angola, Democratic Republic of Congo (DRC), and South-Eastern Brazil, where previously had been demarcated as low-risk regions, have highlighted the possibility of a rapidly changing epidemiology and the potential re-emergence of yellow fever virus (YFV). Furthermore, the first-ever importation of YFV into Asia has highlighted the potential fear of YFV emerging as a global threat. In this review, we describe the changing epidemiology of YF outbreaks, and highlight the use of public health policies, therapeutics, and vaccination as tools to help eliminate future YFV outbreaks.
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