Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.
Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.
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DOI:
10.1007/s40506-020-00237-2
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发表时间:
2020
影响因子:
2
通讯作者:
de Alwis R
中科院分区:
文献类型:
--
作者:
Bifani AM;Ong EZ;de Alwis R
At the turn of the nineteenth century, yellow fever (YF) was considered the most dangerous infectious disease with high case fatality. Subsequent, mass vaccination campaigns coupled with widespread elimination of the YF mosquito vector significantly decreased YF cases and reduced outbreaks to the tropical and subtropical forested regions of Africa and South America. However, recent (2016) large outbreaks in Angola, Democratic Republic of Congo (DRC), and South-Eastern Brazil, where previously had been demarcated as low-risk regions, have highlighted the possibility of a rapidly changing epidemiology and the potential re-emergence of yellow fever virus (YFV). Furthermore, the first-ever importation of YFV into Asia has highlighted the potential fear of YFV emerging as a global threat. In this review, we describe the changing epidemiology of YF outbreaks, and highlight the use of public health policies, therapeutics, and vaccination as tools to help eliminate future YFV outbreaks.
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