Advances in tumor-endothelial cells co-culture and interaction on microfluidics.
Advances in tumor-endothelial cells co-culture and interaction on microfluidics.
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肿瘤内皮细胞共培养及微流控相互作用的进展
DOI：
10.1016/j.jpha.2018.07.005
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发表时间：
2018-08
影响因子：
8.8
通讯作者：
Lin JM
中科院分区：
文献类型：
--
作者：
Li W;Khan M;Mao S;Feng S;Lin JM
癌细胞降解细胞外基质（ECM）并侵入身体周围和远处组织的转移是癌症患者死亡的主要原因。尽管该领域取得了很大进展，但人们对转移的生物学原因却知之甚少。微流控系统提供了先进的技术来重建各种类体内环境，用于研究肿瘤细胞（TC）和内皮细胞（EC）之间的相互作用。本文简要介绍了用于分析TCs-ECs共培养的二维模型和三维微流控系统及其在抗癌药物筛选中的应用。此外，还讨论了在单细胞水平上分析细胞间相互作用的先进方法。
The metastasis in which the cancer cells degrade the extracellular matrix (ECM) and invade to the surrounding and far tissues of the body is the leading cause of mortality in cancer patients. With a lot of advancement in the field, yet the biological cause of metastasis are poorly understood. The microfluidic system provides advanced technology to reconstruct a variety of in vivo-like environment for studying the interactions between tumor cells (TCs) and endothelial cells (ECs). This review gives a brief account of both two-dimensional models and three-dimensional microfluidic systems for the analysis of TCs-ECs co-culture as well as their applications to anti-cancer drug screening. Furthermore, the advanced methods for analyzing cell-to-cell interactions at single-cell level were also discussed.
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影响因子：
14
作者：
Hsiao, Amy Y.;Torisawa, Yu-suke;Tung, Yi-Chung;Sud, Sudha;Taichman, Russell S.;Pienta, Kenneth J.;Takayama, Shuichi
通讯作者：
Takayama, Shuichi
DOI：
10.1016/j.mattod.2015.05.002
发表时间：
2015-12
期刊：
Materials today (Kidlington, England)
影响因子：
--
作者：
Asghar W;El Assal R;Shafiee H;Pitteri S;Paulmurugan R;Demirci U
通讯作者：
Demirci U
模拟血管微环境微流控芯片上肿瘤细胞行为的研究
影响因子：
4.6
作者：
Huang R;Zheng W;Liu W;Zhang W;Long Y;Jiang X
通讯作者：
Jiang X
影响因子：
11.2
作者：
Greene JM;Levy D;Herrada SP;Gottesman MM;Lavi O
通讯作者：
Lavi O
影响因子：
14
作者：
Hosseinkhani, Hossein;Hosseinkhani, Mohsen;Tabata, Yasuhiko
通讯作者：
Tabata, Yasuhiko