Long-Term Health Consequences of SARS-CoV-2: Assumptions Based on SARS-CoV-1 and MERS-CoV Infections.
Long-Term Health Consequences of SARS-CoV-2: Assumptions Based on SARS-CoV-1 and MERS-CoV Infections.
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DOI：
10.3390/diagnostics12081852
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发表时间：
2022-07-31
期刊：
影响因子：
3.6
通讯作者：
Kumar, Subodh
中科院分区：
文献类型：
--
作者：
Khaswal, Ashutosh;Kumar, Vivek;Kumar, Subodh
2019冠状病毒病（COVID-19）是世界历史上最严重的流行病之一。这是在短时间内折磨人类的第三种冠状病毒疾病。世界似乎正在从这一致命的流行病中恢复过来;但人们仍然不清楚其对疾病后健康的影响。很明显，绝大多数COVID-19患者通常会随时间推移而康复;然而，据报道，即使完全康复后，部分患者仍存在疾病表现。已知该疾病在一些患者中留下了不可逆转的损害，预计这些损害会造成轻度或重度的健康影响。除了SARS-CoV-1、MERS-CoV和SARS-CoV-2感染对肺部造成的明显损害外，COVID-19幸存患者在不同器官系统中表现出广泛的功能障碍，与SARS-CoV-1和MERS疾病相似。COVID-19的主要长期表现包括以下方面：（1）中枢神经系统，（2）心血管，（3）肺，（4）胃肠道，（5）血液系统，（6）肾脏和（7）心理社会系统。在大量康复病例中，COVID-19在这些器官及其相关系统中具有疾病显示表现。我们的研究强调了基于对SARS-CoV-1和MERS-CoV的长期影响的理解，由SARS-CoV-2感染引起的大流行的预期身体后果。
Coronavirus Disease-2019 (COVID-19) is one of the worst pandemics in the history of the world. It is the third coronavirus disease that has afflicted humans in a short span of time. The world appears to be recovering from the grasp of this deadly pandemic; still, its post-disease health effects are not clearly understood. It is evident that the vast majority of COVID-19 patients usually recovered over time; however, disease manifestation is reported to still exist in some patients even after complete recovery. The disease is known to have left irreversible damage(s) among some patients and these damages are expected to cause mild or severe degrees of health effects. Apart from the apparent damage to the lungs caused by SARS-CoV-1, MERS-CoV, and SARS-CoV-2 infection, COVID-19-surviving patients display a wide spectrum of dysfunctions in different organ systems that is similar to what occurs with SARS-CoV-1 and MERS diseases. The major long COVID-19 manifestations include the following aspects: (1) central nervous system, (2) cardiovascular, (3) pulmonary, (4) gastrointestinal, (5) hematologic, (6) renal and (7) psycho-social systems. COVID-19 has a disease display manifestation in these organs and its related systems amongst a large number of recovered cases. Our study highlights the expected bodily consequences of the pandemic caused by SARS-CoV-2 infection based on the understanding of the long-term effects of SARS-CoV-1 and MERS-CoV.
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