Evaluation of gut dysbiosis using serum and fecal bile acid profiles.
Evaluation of gut dysbiosis using serum and fecal bile acid profiles.
复制标题
使用血清和粪便胆酸谱评估肠道营养不良。
DOI：
10.12998/wjcc.v10.i34.12484
复制
发表时间：
2022-12-06
影响因子：
1.1
通讯作者：
Honda, Akira
中科院分区：
文献类型：
--
作者：
Monma, Tadakuni;Iwamoto, Junichi;Ueda, Hajime;Tamamushi, Makoto;Kakizaki, Fumio;Konishi, Naoki;Yara, Shoichiro;Miyazaki, Teruo;Hirayama, Takeshi;Ikegami, Tadashi;Honda, Akira
关键词：
肠道菌群失调会影响肠道微生物代谢产物的产生，有毒物质会破坏肠壁的屏障功能，导致各种疾病的发生。梭菌亚群XIVa（XIVa）水平的降低与炎症性肠病（IBD）和艰难梭菌感染（CDI）中发现的肠道生态失调相关。由于XIVa是负责初级胆汁酸（BA）转化为次级BA的细菌群，因此可以通过测定粪便或血清中脱氧胆酸（DCA）/[DCA +胆酸（CA）]的比值来预测肠道XIVa的比例。例如，血清DCA/（DCA+CA）在IBD患者中显著低于健康对照，即使在缓解期也是如此。这些结果表明，IBD患者肠道XIVa的比例低可能是IBD发病的先决条件，但不是肠道炎症的后果。另一份报告显示，血清DCA/（DCA + CA）比值降低可预测对CDI的易感性。因此，BA谱，特别是继发性BA与原发性BA的比率，可以作为由XIVa降低引起的肠道生态失调的替代标志物。
Dysbiosis in the intestinal microflora can affect the gut production of microbial metabolites, and toxic substances can disrupt the barrier function of the intestinal wall, leading to the development of various diseases. Decreased levels of Clostridium subcluster XIVa (XIVa) are associated with the intestinal dysbiosis found in inflammatory bowel disease (IBD) and Clostridium difficile infection (CDI). Since XIVa is a bacterial group responsible for the conversion of primary bile acids (BAs) to secondary BAs, the proportion of intestinal XIVa can be predicted by determining the ratio of deoxycholic acid (DCA)/[DCA + cholic acid (CA)] in feces orserum. For example, serum DCA/(DCA+CA) was significantly lower in IBD patients than in healthy controls, even in the remission period. These results suggest that a low proportion of intestinal XIVa in IBD patients might be a precondition for IBD onset but not a consequence of intestinal inflammation. Another report showed that a reduced serum DCA/(DCA + CA) ratio could predict susceptibility to CDI. Thus, the BA profile, particularly the ratio of secondary to primary BAs, can serve as a surrogate marker of the intestinal dysbiosis caused by decreased XIVa.
登录
查看更多内容
影响因子：
24.5
作者：
Joossens, Marie;Huys, Geert;Vermeire, Severine
通讯作者：
Vermeire, Severine
影响因子：
64.8
作者：
Funabashi, Masanori;Grove, Tyler L.;Fischbach, Michael A.
通讯作者：
Fischbach, Michael A.
炎症性肠病发病机理的进展：将宿主遗传学和微生物组联系起来。
影响因子：
24.5
作者：
Knights D;Lassen KG;Xavier RJ
通讯作者：
Xavier RJ
小儿炎症性肠病患者亲属中与疾病相关的微生物和代谢组学状态。
DOI：
10.1016/j.jcmgh.2016.06.004
发表时间：
2016-11
影响因子：
7.2
作者：
Jacobs JP;Goudarzi M;Singh N;Tong M;McHardy IH;Ruegger P;Asadourian M;Moon BH;Ayson A;Borneman J;McGovern DP;Fornace AJ Jr;Braun J;Dubinsky M
通讯作者：
Dubinsky M
影响因子：
4.9
作者：
Bamba, Shigeki;Inatomi, Osamu;Nishida, Atsushi;Ohno, Masashi;Imai, Takayuki;Takahashi, Kenichiro;Naito, Yuji;Iwamoto, Junichi;Honda, Akira;Inohara, Naohiro;Andoh, Akira
通讯作者：
Andoh, Akira