Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution.
Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution.
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DOI：
10.1289/ehp.0901725
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发表时间：
2010-08
影响因子：
10.4
通讯作者：
Loft S
中科院分区：
文献类型：
--
作者：
Møller P;Loft S
空气污染被认为通过氧化应激对健康造成影响，氧化应激会对DNA和脂质造成损害。我们确定了人体细胞或体液中氧化损伤的DNA和脂质过氧化产物的水平是否为生物有效剂量的有用生物标志物，用于研究暴露于燃烧过程中的颗粒物(PM)对健康的影响。我们确认了在PubMed和EMBASE中报道了环境暴露于PM与DNA和脂质氧化损伤之间估计关联的出版物。我们还从参考文献列表和《科学网》上引用的文章中确定了出版物。对于每项研究，我们获得了关于估计效应量的信息，以计算标准化的平均差异(无单位)，并确定了在暴露评估和每个生物标记物的分析中出错的可能性，用于全面和分层的形式荟萃分析。在Meta分析中，接触者和非接触者之间氧化DNA和血脂的标化平均差异(95%可信区间)分别为0.53(0.29~0.76)和0.73(0.18~1.28)，尿中分别为0.52(0.22~0.82)和0.49(0.01~0.97)。呼吸道氧化脂质的标化平均差为0.64(0.07~1.21)。将分析限制到不太可能有实质性生物标志物或暴露测量误差的研究、可能有生物标志物和/或暴露误差的研究、或可能同时有两个误差源的研究分别导致标准化平均差异0.55(0.19-0.90)、0.66(0.37-0.95)和0.65(0.34-0.96)。暴露在燃烧颗粒物中与人体DNA和脂质的氧化损伤一致，这表明这些测量结果可能被用作生物有效剂量的生物标记物。
Air pollution is thought to exert health effects through oxidative stress, which causes damage to DNA and lipids. We determined whether levels of oxidatively damaged DNA and lipid peroxidation products in cells or bodily fluids from humans are useful biomarkers of biologically effective dose in studies of the health effects of exposure to particulate matter (PM) from combustion processes. We identified publications that reported estimated associations between environmental exposure to PM and oxidative damage to DNA and lipids in PubMed and EMBASE. We also identified publications from reference lists and articles cited in the Web of Science. For each study, we obtained information on the estimated effect size to calculate the standardized mean difference (unitless) and determined the potential for errors in exposure assessment and analysis of each of the biomarkers, for total and stratified formal meta-analyses. In the meta-analysis, the standardized mean differences (95% confidence interval) between exposed and unexposed subjects for oxidized DNA and lipids were 0.53 (0.29–0.76) and 0.73 (0.18–1.28) in blood and 0.52 (0.22–0.82) and 0.49 (0.01–0.97) in urine, respectively. The standardized mean difference for oxidized lipids was 0.64 (0.07–1.21) in the airways. Restricting analyses to studies unlikely to have substantial biomarker or exposure measurement error, studies likely to have biomarker and/or exposure error, or studies likely to have both sources of error resulted in standardized mean differences of 0.55 (0.19–0.90), 0.66 (0.37–0.95), and 0.65 (0.34–0.96), respectively. Exposure to combustion particles is consistenly associated with oxidatively damaged DNA and lipids in humans, suggesting that it is possible to use these measurements as biomarkers of biologically effective dose.
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影响因子：
2.1
作者：
Allen J;Trenga CA;Peretz A;Sullivan JH;Carlsten CC;Kaufman JD
通讯作者：
Kaufman JD
影响因子：
10.4
作者：
Chen C;Arjomandi M;Balmes J;Tager I;Holland N
通讯作者：
Holland N
超铁颗粒在空气颗粒质量与心血管健康之间关联中的潜在作用。
影响因子：
10.4
作者：
Delfino RJ;Sioutas C;Malik S
通讯作者：
Malik S
DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
4.8
作者：
Gedik, CM;Collins, A;Vaughan, N
通讯作者：
Vaughan, N