Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults.
Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults.
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DOI：
10.1289/ehp.10294
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Holland N
中科院分区：
文献类型：
--
作者：
Chen C;Arjomandi M;Balmes J;Tager I;Holland N
越来越多的证据表明氧化损伤在慢性疾病中起作用。尽管臭氧（O₃）是一种许多人都会接触到的氧化性污染物，但很少有研究探讨臭氧是否会在人体内诱发氧化应激。
本研究旨在评估短期和长期接触臭氧对健康个体氧化应激生物标志物的影响。
对两组健康大学生的脂质过氧化生物标志物8 - 异前列腺素（8 - iso - PGF）和血浆铁还原能力（FRAP，一种抗氧化能力指标）进行了分析，这两组学生在其一生中以及之前的暑假期间所接触的环境臭氧水平差异较大，他们分别来自洛杉矶（LA，n = 59）或旧金山湾区（SF，n = 61）。
估计的2周、1个月和一生的臭氧暴露量与8 - iso - PGF升高显著相关。夏季较高的暴露量导致洛杉矶组的8 - iso - PGF水平高于旧金山组（p = 0.02）。在每个地区内，男性和女性的8 - iso - PGF水平相似。未观察到FRAP的地区差异，但两组中男性的FRAP均显著较高（旧金山组：p = 0.002；洛杉矶组：p = 0.004）。一项暴露舱亚研究（n = 15）还显示，在暴露于200 ppb臭氧4小时后，8 - iso - PGF显著升高，FRAP受到抑制，两种生物标志物在18小时后都接近恢复正常。
长期暴露于臭氧与8 - iso - PGF升高有关，这表明8 - iso - PGF是与空气污染相关的氧化损伤的良好生物标志物。
There is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O3 induces oxidative stress in humans. This study was designed to assess the effect of short-and long-term O3 exposures on biomarkers of oxidative stress in healthy individuals. Biomarkers of lipid peroxidation, 8-isoprostane (8-iso-PGF), and antioxidant capacity ferric reducing ability of plasma (FRAP) were analyzed in two groups of healthy college students with broad ranges of ambient O3 exposure during their lifetimes and previous summer recess either in Los Angeles (LA, n = 59) or the San Francisco Bay Area (SF, n = 61). Estimated 2-week, 1-month, and lifetime O3 exposures were significantly correlated with elevated 8-iso-PGF. Elevated summertime exposures resulted in the LA group having higher levels of 8-iso-PGF than the SF group (p = 0.02). Within each location, males and females had similar 8-iso-PGF. No regional difference in FRAP was observed, with significantly higher FRAP in males in both groups (SF: p = 0.002; LA: p = 0.004). An exposure chamber substudy (n = 15) also showed a significant increase in 8-iso-PGF as well as an inhibition of FRAP immediately after a 4-hr exposure to 200 ppb O3, with near normalization by 18 hr in both biomarkers. Long-term exposure to O3 is associated with elevated 8-iso-PGF, which suggests that 8-iso-PGF is a good biomarker of oxidative damage related to air pollution.
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影响因子：
3.5
作者：
Corradi, M;Alinovi, R;Mutti, A
通讯作者：
Mutti, A
影响因子：
3.8
作者：
Devlin, RB;McDonnell, WF;Koren, HS
通讯作者：
Koren, HS
影响因子：
3.2
作者：
Lopes, HF;Morrow, JD;Egan, BM
通讯作者：
Egan, BM
影响因子：
7.1
作者：
Halliwell, Barry;Chirico, Susanna
通讯作者：
Chirico, Susanna
影响因子：
6.7
作者：
Ke, RW;Pace, DT;Ahokas, A
通讯作者：
Ahokas, A