Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory.
Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory.
复制标题
DOI：
10.1016/j.nicl.2021.102722
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Uhlhaas PJ
中科院分区：
文献类型：
--
作者：
Cruz G;Grent-'t-Jong T;Krishnadas R;Palva JM;Palva S;Uhlhaas PJ
长程时间相关性不能反映精神病的临床轨迹。降低的长程时间相关性可能出现在精神病发作时。抗精神病药物可能影响长程时间相关性。长程时间相关性与精神病症状无关。长距离时间相关性（LRTC）反映了大脑最佳处理信息的能力。先前的研究表明，慢性精神分裂症患者在α和β振荡时表现出改变的LRTC。然而，目前尚不清楚在精神分裂症的哪个阶段出现异常LRTC。为了解决这个问题，我们研究了从情感障碍和物质滥用患者（临床上处于精神病低风险，CHR-N），临床上处于精神病高风险的患者（CHR-P）（n = 115）以及首次发作的患者（FEP）（n = 25）中获得的静息态脑磁图（MEG）记录中的LRTC。对照组为47例健康体检者。LRTC获得的频率从4到40赫兹，并与临床和神经心理学数据。此外，我们研究了LRTC与CHR-P参与者向精神病转变之间的关系，以及LRTC与FEP参与者抗精神病药物之间的关系。我们的研究结果表明，临床组的参与者与对照组有相似的LRTC。此外，LRTC与参与者的临床和神经认知变量无关，也不能预测向精神病的转变。因此，受损的LRTC并不反映精神病临床轨迹的特征。然而，减少LRTC在β-波段超过后传感器的药物FEP参与者表明，改变LRTC可能出现在发病。未来的研究需要阐明抗精神病药物在改变LRTC中的作用。
Long Range Temporal Correlations do not reflect the clinical trajectory of psychosis. Reduced Long Range Temporal Correlations may appear at the onset of psychosis. Antipsychotic medication may affect Long Range Temporal Correlations. Long Range Temporal Correlations do not correlate with symptoms of psychosis. Long-Range Temporal Correlations (LRTCs) index the capacity of the brain to optimally process information. Previous research has shown that patients with chronic schizophrenia present altered LRTCs at alpha and beta oscillations. However, it is currently unclear at which stage of schizophrenia aberrant LRTCs emerge. To address this question, we investigated LRTCs in resting-state magnetoencephalographic (MEG) recordings obtained from patients with affective disorders and substance abuse (clinically at low-risk of psychosis, CHR-N), patients at clinical high-risk of psychosis (CHR-P) (n = 115), as well as patients with a first episode (FEP) (n = 25). Matched healthy controls (n = 47) served as comparison group. LRTCs were obtained for frequencies from 4 to 40 Hz and correlated with clinical and neuropsychological data. In addition, we examined the relationship between LRTCs and transition to psychosis in CHR-P participants, and the relationship between LRTC and antipsychotic medication in FEP participants. Our results show that participants from the clinical groups have similar LRTCs to controls. In addition, LRTCs did not correlate with clinical and neurocognitive variables across participants nor did LRTCs predict transition to psychosis. Therefore, impaired LRTCs do not reflect a feature in the clinical trajectory of psychosis. Nevertheless, reduced LRTCs in the beta-band over posterior sensors of medicated FEP participants indicate that altered LRTCs may appear at the onset of the illness. Future studies are needed to elucidate the role of anti-psychotic medication in altered LRTCs.
登录
查看更多内容
急性氯胺酮会使精神分裂症患者丘脑-皮层回路中与任务相关的伽马波段振荡失调。
DOI：
10.1093/brain/awy175
发表时间：
2018-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Grent-'t-Jong T;Rivolta D;Gross J;Gajwani R;Lawrie SM;Schwannauer M;Heidegger T;Wibral M;Singer W;Sauer A;Scheller B;Uhlhaas PJ
通讯作者：
Uhlhaas PJ
影响因子：
64.8
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
DOI：
10.1016/j.nicl.2020.102485
发表时间：
2020
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Alamian G;Pascarella A;Lajnef T;Knight L;Walters J;Singh KD;Jerbi K
通讯作者：
Jerbi K
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison
影响因子：
10.6
作者：
Anticevic, Alan;Corlett, Philip R.;Krystal, John H.
通讯作者：
Krystal, John H.