An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant.
An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant.
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DOI：
10.1111/cts.13393
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发表时间：
2022-11
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影响因子：
--
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中科院分区：
文献类型：
--
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母乳是婴儿的最佳营养。然而，尽管母乳中人类衍生代谢物（如脂质和低聚糖）经常被报道，但外源性化学物质（如药物、食品和合成化合物）的存在往往没有得到解决。为了了解可能存在的外源性化合物的类型，通过非靶向代谢组学分析了人乳（n = 996）。该分析显示，在母乳中发现了生活方式分子，如药物及其代谢物，以及工业来源，如增塑剂、化妆品和其他个人护理产品。我们提供了进一步的证据，这些生活方式的分子也可以在新生儿的粪便中检测到。因此，这项研究对婴儿可能因生活方式选择、暴露或哺乳父母的医疗状况而摄入母乳的暴露类型提供了重要的见解。
Human milk is the optimal infant nutrition. However, although human‐derived metabolites (such as lipids and oligosaccharides) in human milk are regularly reported, the presence of exogenous chemicals (such as drugs, food, and synthetic compounds) are often not addressed. To understand the types of exogenous compounds that might be present, human milk (n = 996) was analyzed by untargeted metabolomics. This analysis revealed that lifestyle molecules, such as medications and their metabolites, and industrial sources, such as plasticizers, cosmetics, and other personal care products, are found in human milk. We provide further evidence that some of these lifestyle molecules are also detectable in the newborn's stool. Thus, this study gives important insight into the types of exposures infants receiving human milk might ingest due to the lifestyle choices, exposure, or medical status of the lactating parent.
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影响因子：
16.6
作者：
Scheubert K;Hufsky F;Petras D;Wang M;Nothias LF;Dührkop K;Bandeira N;Dorrestein PC;Böcker S
通讯作者：
Böcker S
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
影响因子：
2.1
作者：
Demmelmair, Hans;Koletzko, Berthold
通讯作者：
Koletzko, Berthold
影响因子：
5.2
作者：
Waitt, Catriona John;Garner, Paul;Else, Laura Jayne
通讯作者：
Else, Laura Jayne
影响因子：
5.1
作者：
Kuppala, Venkata S.;Meinzen-Derr, Jareen;Morrow, Ardythe L.;Schibler, Kurt R.
通讯作者：
Schibler, Kurt R.