Development of a novel postnatal neurobehavioral scale for evaluation of common marmoset monkeys.
Development of a novel postnatal neurobehavioral scale for evaluation of common marmoset monkeys.
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DOI：
10.1002/ajp.22356
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发表时间：
2015-04
影响因子：
2.4
通讯作者：
Emborg, Marina E.
中科院分区：
文献类型：
--
作者：
Braun, Katarina;Schultz-Darken, Nancy;Schneider, Mary;Moore, Colleen F.;Emborg, Marina E.
与恒河猴（Macaca mullatta）相比，普通绒猴（Callithrix jacchus）在疾病建模方面具有几个优势，特别是转基因举措，因为它们通常会生下双胞胎，这增加了样本量，加速了发育，寿命较短，便于分析年龄相关疾病的发作。然而，目前还没有工具可以评估绒猴在生命最初的第一个月内的神经发育。在这里，我们报告了一种新的灵长类动物出生后神经行为评估量表（PPNAS-M）的基础上，目前可用的人类和恒河猴的规模。对来自12个家庭的24只健康绒猴幼崽（12只雌性，12只雄性）进行了评估。婴儿评估包括在出生后15天和30天进行的10分钟测试。PPNAS-M由41项非侵入性测试组成，分为5个测试类别：视觉定向，听觉和空间定向，运动反应，翻正和身体力量以及气质测试。在这两个年龄段进行的测试并没有影响婴儿的整体健康，这表明PPNAS-M是一种非侵入性的测试工具。显着的成熟证明了从出生后第15天至30天的五个测试类别中的每一个增加的分数，与独特的绒猴的发展模式。主成分分析定义了4个项目组（定向，状态控制，运动成熟度和感觉灵敏度），每个项目组有5个变量。方向和状态控制因素是高度相似的，在这两个年龄段和高度相关的项目分组与恒河猴。我们的研究结果表明，PPNAS-M是一个有用的评估工具，用于检测神经运动，注意力，和气质状态的婴儿绒猴，它是敏感的发育影响。进一步的研究，以验证PPNAS-M评估正常发育与产前暴露和转基因相关的发育扰动的早期影响是必要的。
Common marmoset (Callithrix jacchus) monkeys when compared to rhesus macaques (Macaca mullatta) present several advantages for disease modeling, especially transgenic initiatives, as they commonly give birth to twins, which increases sample size, have accelerated development and a shorter life span that facilitates the analysis of the onset of age-related diseases. Yet, no tools are currently available to assess marmoset neurodevelopment during the initial first month of life. Here we report the creation of a novel Primate Postnatal Neurobehavioral Assessment Scale for marmoset monkeys (PPNAS-M) that was based on currently available scales for human and rhesus monkeys. Twenty-four healthy marmoset infants (12 females, 12 males) from 12 families were evaluated. The infant assessments involved 10-minute testing administered at 15 and 30 days after birth. The PPNAS-M consists of 41 noninvasive tests grouped into 5 testing categories: visual orienting, auditory and spatial orienting, motor responses, righting and body strength, and temperament tests. Testing at these two ages did not affect the overall health of the infants, suggesting that the PPNAS-M is a non-invasive testing tool. Significant maturation was demonstrated by increased scores in each of the five testing categories from postnatal day 15 to 30, with developmental patterns unique to marmosets. Principal component analysis defined 4 item groups (Orientation, State Control, Motor Maturity and Sensory Sensitivity) with 5 variables each. Orientation and State Control factors were highly similar at both ages and correlated highly with previous item groupings used with rhesus macaques. Our results indicate that the PPNAS-M is a useful assessment tool for detecting neuromotor, attention, and temperament status of infant marmosets and that it is sensitive to developmental effects. Further studies to validate the PPNAS-M for the assessment of normal development versus early effects of developmental perturbations associated to prenatal exposures and transgenesis are warranted.
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DOI：
10.2307/1165848
发表时间：
1978-01-01
影响因子：
9.5
作者：
Als, H
通讯作者：
Als, H
影响因子：
3.4
作者：
Pryce, Christopher R.;Aubert, Yves;Maier, Claudia;Pearce, Peter C.;Fuchs, Eberhard
通讯作者：
Fuchs, Eberhard
影响因子：
2.4
作者：
Pistorio, Ashley L.;Vintch, Brett;Wang, Xiaoqin
通讯作者：
Wang, Xiaoqin
影响因子：
2.5
作者：
Hendrickson, Anita;Troilo, David;Springer, Alan
通讯作者：
Springer, Alan
影响因子：
2.2
作者：
Coe, Christopher L.;Lubach, Gabriele R.;Schneider, Mary L.
通讯作者：
Schneider, Mary L.