The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.
The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.
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DOI：
10.1007/s00213-010-1989-2
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发表时间：
2011-03
影响因子：
3.4
通讯作者：
Fuchs, Eberhard
中科院分区：
文献类型：
--
作者：
Pryce, Christopher R.;Aubert, Yves;Maier, Claudia;Pearce, Peter C.;Fuchs, Eberhard
关键词：
未成熟哺乳动物大脑暴露于应激因素，包括产前或产后糖皮质激素的应激水平，被认为是短期和长期脑功能的主要调节因素，在人类中，是神经精神疾病的主要病因因素。实验性人体研究不可行，需要动物研究来证明因果关系和阐明机制。在啮齿类动物中进行和审查了一些研究，但在灵长类动物中进行的研究相对较少。本文综述了我们已发表的关于以下方面的研究和一些原始数据：（1）产前应激对幼年-青春期恒河猴下丘脑-垂体-肾上腺（HPA）反应性和海马神经解剖结构的影响;（2）产前地塞米松（DEX）对幼年-青春期普通绒猴HPA活性、行为和前额叶皮质神经解剖结构的影响;（3）出生后每日父母分离应激对幼仔期普通绒猴HPA反应活性、行为、睡眠以及海马和前额叶皮层神经解剖学的影响。产前应激增加猕猴的基础皮质醇水平和减少神经发生。产前DEX对绒猴的HPA活性没有影响，并减少了绒猴的社交游戏和熟练的运动行为。出生后的社会压力增加基础皮质醇水平，减少社会发挥，增加觉醒和减少海马糖皮质激素和盐皮质激素受体表达的绒猴。围产期应激相关的环境事件产生短期和长期影响HPA功能，行为和大脑状态的恒河猴和普通绒猴。介导持久效应的机制仍有待阐明，候选者包括基础HPA功能增加和表观遗传编程。
Exposure of the immature mammalian brain to stress factors, including stress levels of glucocorticoids, either prenatally or postnatally, is regarded as a major regulatory factor in short- and long-term brain function and, in human, as a major aetiological factor in neuropsychiatric disorders. Experimental human studies are not feasible and animal studies are required to demonstrate causality and elucidate mechanisms. A number of studies have been conducted and reviewed in rodents but there are relatively few studies in primates. Here we present an overview of our published studies and some original data on the effects of: (1) prenatal stress on hypothalamic–pituitary–adrenal (HPA) re/activity and hippocampus neuroanatomy in juvenile-adolescent rhesus macaques; (2) prenatal dexamethasone (DEX) on HPA activity, behaviour and prefrontal cortex neuroanatomy in infant-adolescent common marmosets; (3) postnatal daily parental separation stress on HPA re/activity, behaviour, sleep and hippocampus and prefrontal cortex neuroanatomy in infant-adolescent common marmoset. Prenatal stress increased basal cortisol levels and reduced neurogenesis in macaque. Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset. Postnatal social stress increased basal cortisol levels, reduced social play, increased awakening and reduced hippocampal glucocorticoid and mineralocorticoid receptor expression in marmoset. Perinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset. The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.
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