Identification of tumour-infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma.
Identification of tumour-infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma.
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鉴定与肺鳞状细胞癌总体生存相关的肿瘤浸润骨髓亚群
DOI：
10.1002/path.6015
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发表时间：
2023-01
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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肺鳞状细胞癌（LUSC）是肺癌的主要亚型，治疗疗法有限，预后不良，肿瘤吸收的髓样细胞（TIMS）是LUSC的关键调节剂，但是Tim子类型和LUS临床量的较低量与较低的范围之间的相关性。基于髓样细胞的C使用502名LUSC患者的免疫组织化学对肿瘤中的TIM标记和基质区域进行了定量。 ression并预测潜在的药物靶标和治疗剂。通过降低的肿瘤细胞，CD8+ T细胞的耗尽模式，在高危患者中，肿瘤细胞的降低和化合物调节越来越多的疗程可帮助您的第一个预言，这可能会使肌动症的临床，这可能会使肌动症的临床介绍，这可能会使您的第一个预言inders upercons，这可能会识别出第一个预后的人群，这可能会使肿瘤的转变和肿瘤细胞衰竭模式的降低。约翰·威利（John Wiley＆Sons Ltd）代表大不列颠和爱尔兰的病理学会。
Lung squamous cell carcinoma (LUSC) is a primary subtype of lung cancer with limited therapeutic options and poor prognosis, and tumour‐infiltrating myeloid cells (TIMs) are key regulators of LUSC. However, the correlation between the abundance of TIM subtypes and clinical outcomes of LUSC remains unexplored. This study aimed to develop and validate a prognostic model for low‐ and high‐risk patients with LUSC based on myeloid cell microenvironments. TIM markers in the tumoural (T) and stromal (S) regions were quantified using immunohistochemistry for 502 LUSC patients. L1‐penalized Cox regression was used to develop a myeloid survival score (MSS) model based on the training cohort, followed by validation in distinct cohorts from multiple centres. RNA sequencing and immunostaining were used to examine the mechanisms of myeloid cells in LUSC progression and predict potential drug targets and therapeutic agents. Of the 12 myeloid markers, CD163T, CD163S, and S100A12T were highly associated with overall survival (OS) in LUSC patients. The MSS of the three myeloid signatures accurately categorized LUSC patients into risk categories, with an observable difference in OS between the training and validation cohorts. Tumours with high MSS were associated with enhanced antioxidative ability and hedgehog signalling and a shift to a more pro‐tumorigenic microenvironment, accompanied by a reduced tumour cell immunogenicity and increased CD8+ T cell exhaustion patterns. Additionally, in high‐risk patients, potential drug targets and compounds regulating hedgehog signalling were identified. Our study provides the first prognostic myeloid signature for LUSC, which may help advance precision medicine. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
--
作者：
Checa-Rojas A;Delgadillo-Silva LF;Velasco-Herrera MDC;Andrade-Domínguez A;Gil J;Santillán O;Lozano L;Toledo-Leyva A;Ramírez-Torres A;Talamas-Rohana P;Encarnación-Guevara S
通讯作者：
Encarnación-Guevara S
影响因子：
7.3
作者：
Elliott LA;Doherty GA;Sheahan K;Ryan EJ
通讯作者：
Ryan EJ
DOI：
10.1084/jem.20200264
发表时间：
2021-01-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gerhard GM;Bill R;Messemaker M;Klein AM;Pittet MJ
通讯作者：
Pittet MJ
影响因子：
7.3
作者：
Meding, Stephan;Balluff, Benjamin;Walch, Axel
通讯作者：
Walch, Axel