Solvent-resistant antibacterial microfibers of self-quaternized block copolymers from atom transfer radical polymerization and electrospinning
Solvent-resistant antibacterial microfibers of self-quaternized block copolymers from atom transfer radical polymerization and electrospinning
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原子转移自由基聚合和静电纺丝自季铵化嵌段共聚物耐溶剂抗菌微纤维
DOI：
10.1039/b716127a
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发表时间：
2008-02
影响因子：
--
通讯作者：
Yao, F
中科院分区：
文献类型：
--
作者：
Li, XS;Fu, GD;Li, ZG;Yao, F
采用连续原子转移自由基聚合法（ATRP）合成了一段聚[（2-二甲氨基）甲基丙烯酸乙酯)-co-（甲基丙烯酸缩水甘油酯）]P（DMAEMA-c-GMA）和一段聚（五氯苯基丙烯酸酯）（PPCPA） （P(DMAEMA-c-GMA)-b-PPCPA）的双嵌段共聚物。P(DMAEMA-c-GMA)-b-PPCPA在THF和DMF溶液中电纺丝得到了直径在300 nm至1.3 μm之间的微纤维。随后用1,6-己二胺处理得到耐溶剂微纤维。P（DMAEMA-c-GMA）链段叔胺基被PPCPA链段的氯芳香族化合物烷基化（或P(DMAEMA-c-GMA)-b-PPCPA自季铵化）生成季铵盐（QASs）。PPCPA的疏水相互作用与P(DMAEMA-c-GMA)-b-PPCPA自季铵化产生的QASs的静电相互作用相结合，使所得的微纤维具有较高的抗菌活性。用大肠杆菌和金黄色葡萄球菌培养物检测交联微纤维的抑菌效果。50 mg P(DMAEMA-c-GMA)-b-PPCPA微纤维接触10 min后，95%大肠杆菌和97%金黄色葡萄球菌死亡。自季铵化P(DMAEMA-c-GMA)-b-PPCPA微纤维的抗菌活性也在多次应用中得到证实。
Diblock copolymers with one block of poly[((2-dimethylamino)ethyl methacrylate)-co-(glycidyl methacrylate)] P(DMAEMA-c-GMA) and another of poly(pentachlorophenyl acrylate) (PPCPA) (P(DMAEMA-c-GMA)-b-PPCPA) were synthesized via consecutive atom transfer radical polymerization (ATRP). Electrospinnning of P(DMAEMA-c-GMA)-b-PPCPA from a solution in THF and DMF gave rise to microfibers with diameters in the range of 300 nm to 1.3 μm. Solvent-resistant microfibers were obtained by the subsequent treatment with 1,6-hexanediamine. The quaternary ammonium salts (QASs) were generated viaN-alkylation of tertiary amine groups of the P(DMAEMA-c-GMA) block by the chloro-aromatic compounds of the PPCPA block (or self-quaternization of P(DMAEMA-c-GMA)-b-PPCPA). Combination of the hydrophobic interaction of the PPCPA and the electrostatic interaction of QASs from the self-quaternization of P(DMAEMA-c-GMA)-b-PPCPA gives the resulting microfibers a high antibacterial activity. The antibacterial effect of the crosslinked microfibers was assayed with Escherichia coli and Staphylococcus aureus cultures. 95% E. coli and 97% S. aureus were killed after being contacted with 50 mg P(DMAEMA-c-GMA)-b-PPCPA microfibers in 10 min. The permanence of the antibacterial activity of the self-quaternized P(DMAEMA-c-GMA)-b-PPCPA microfibers was also demonstrated in repeated applications.
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影响因子：
6
作者：
Xu, Xiaoyi;Yang, Qingbiao;Jing, Xiabin
通讯作者：
Jing, Xiabin
影响因子：
6.2
作者：
E. Yancheva;D. Paneva;V. Maximova;L. Mespouille;P. Dubois;N. Manolova;Iliya B Rashkov
通讯作者：
E. Yancheva;D. Paneva;V. Maximova;L. Mespouille;P. Dubois;N. Manolova;Iliya B Rashkov
影响因子：
5.5
作者：
Valéry Rebizant;V. Abetz;F. Tournilhac;François Court;L. Leibler
通讯作者：
Valéry Rebizant;V. Abetz;F. Tournilhac;François Court;L. Leibler
影响因子：
15
作者：
Melaiye, A;Sun, ZH;Youngs, WJ
通讯作者：
Youngs, WJ
影响因子：
3.7
作者：
Jin, Ming;Zhang, Xintong;Fujishima, Akira
通讯作者：
Fujishima, Akira