Untangling the Tauopathy for Alzheimer's disease and parkinsonism.
Untangling the Tauopathy for Alzheimer's disease and parkinsonism.
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DOI：
10.1186/s12929-018-0457-x
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发表时间：
2018-07-10
影响因子：
11
通讯作者：
Chiang AS
中科院分区：
文献类型：
--
作者：
Chang HY;Sang TK;Chiang AS
Tau是一种微管相关蛋白，主要定位于轴突以稳定轴突微管结构和神经元连接。Tau病理学是最常见的蛋白质病之一，与年龄依赖性神经退行性疾病（包括阿尔茨海默病（AD）和各种帕金森氏症）相关。Tau蛋白经历过多的分子内修饰，并且一些改变的形式促进毒性寡聚体Tau和成对螺旋丝的产生，并且通过其进一步组装成神经元缠结，也称为Tau病。本文就Tau蛋白病的研究进展进行综述，主要介绍Tau蛋白病与轴突运输缺陷的早期表现、轴突线粒体应激、自噬囊泡积聚和轴突破坏的进行以及Tau蛋白在突触中的传播等方面的关系。目前，通过靶向tau蛋白本身或通过改善与年龄相关的生理衰退的两种替代策略正在竞相寻找治疗tau蛋白病的希望。毫无疑问，需要更多的研究来对抗这种已经影响到我们老龄化人口中数百万人的毁灭性疾病。
Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including Alzheimer’s disease (AD), and various Parkinsonism. Tau protein undergoes a plethora of intra-molecular modifications and some altered forms promote the production of toxic oligomeric tau and paired helical filaments, and through which further assemble into neurofibrillary tangles, also known as tauopathy. In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse. Two alternative strategies either by targeting tau protein itself or by improving the age-related physiological decline are currently racing to find the hopeful treatment for tauopathy. Undoubtedly, more studies are needed to combat this devastating condition that has already affected millions of people in our aging population.
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影响因子：
3.5
作者：
Butzlaff, Malte;Hannan, Shabab B.;Voigt, Aaron
通讯作者：
Voigt, Aaron
DOI：
10.1038/nrm.2017.53
发表时间：
2017-10
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Ray Chaudhuri A;Nussenzweig A
通讯作者：
Nussenzweig A
影响因子：
8.9
作者：
Caselli RJ;Beach TG;Knopman DS;Graff-Radford NR
通讯作者：
Graff-Radford NR
影响因子：
4
作者：
Choi, Jee-Eun;Mostoslavsky, Raul
通讯作者：
Mostoslavsky, Raul
影响因子：
--
作者：
Boyapati RK;Tamborska A;Dorward DA;Ho GT
通讯作者：
Ho GT