Effects of gut microbes on nutrient absorption and energy regulation.

Effects of gut microbes on nutrient absorption and energy regulation.
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肠道微生物对营养吸收和能量调节的影响。

DOI:
10.1177/0884533611436116
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发表时间:
2012-04
期刊:
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
影响因子:
--
通讯作者:
DiBaise JK
DiBaise JK
中科院分区:
其他
文献类型:
--
作者:
Krajmalnik-Brown R;Ilhan ZE;Kang DW;DiBaise JK

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营养不良可能表现为肥胖或营养不良。越来越多的证据表明,肠道微生物群在从饮食中获取能量的收获、储存和消耗中起着重要作用。肠道菌群的组成已被证明在瘦弱和肥胖的人和老鼠之间是不同的;然而,个体肠道微生物在能量收集中发挥的具体作用仍不确定。肠道菌群也可能通过全身暴露于源自肠道菌群的细菌脂多糖,影响以慢性低水平炎症(如肥胖)为特征的疾病的发展。这篇综述探讨了肠道微生物群在能量收集和脂肪储存中的作用,以及在肥胖和营养不良中微生物群的差异。
Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet. The composition of the gut microbiota has been shown to differ between lean and obese humans and mice; however, the specific roles that individual gut microbes play in energy harvest remain uncertain. The gut microbiota may also influence the development of conditions characterized by chronic low-level inflammation, such as obesity, through systemic exposure to bacterial lipopolysaccharide derived from the gut microbiota. In this review, the role of the gut microbiota in energy harvest and fat storage is explored, as well as differences in the microbiota in obesity and undernutrition.
DOI: 10.2337/db06-1491
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