An fMRI study on cortical responses during active self-touch and passive touch from others.
An fMRI study on cortical responses during active self-touch and passive touch from others.
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DOI：
10.3389/fnbeh.2012.00051
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发表时间：
2012
影响因子：
3
通讯作者：
McGlone F
中科院分区：
文献类型：
--
作者：
Ackerley R;Hassan E;Curran A;Wessberg J;Olausson H;McGlone F
主动的、自我的触摸和来自外部源的被动的触摸在被触摸的皮肤部位调动相似的传入机械感受器。然而，与有毛皮肤相比，触摸无毛皮肤会激活不同类型的传入机械感受器。尽管不同身体部位的触觉感知相似，但很可能是触觉信息的处理方式不同。在本研究中，我们使用功能性磁共振成像（fMRI）来阐明在主动触摸、自我触摸和被动触摸他人时，在无毛（手掌）和有毛（手臂）皮肤上，用软刷作为刺激时，触摸表征的神经信号的皮层差异。有两种主动触摸条件，参与者用右手的刷子抚摸左手掌或手臂。有两种类似的被动触摸条件，实验者用相同的刷子抚摸参与者的手掌和手臂的相同区域。触摸左手掌在右侧感觉运动区引发了一个大的、显著的、阳性的血氧水平依赖（BOLD）信号。触摸手臂的活动较少。在右侧初级体感皮层（SI）的Brodmann区（BA） 3中，分别发现了手掌和手臂的体外感表征，在这两个区域，主动抚摸产生的信号明显高于被动抚摸。与静息基线相比，活跃的自我触摸在左半球感觉运动皮质区域网络中引发了一个积极的BOLD信号。相比之下，在被动触摸时，左侧SI中发现明显的负BOLD信号。因此，尽管传入信号或诱发知觉相似，但这四种情况中的每一种都有独特的皮层特征。据推测，注意机制在右脑SI的触摸信号调制中起作用，解释了主动和被动触摸之间的差异。
Active, self-touch and the passive touch from an external source engage comparable afferent mechanoreceptors on the touched skin site. However, touch directed to glabrous skin compared to hairy skin will activate different types of afferent mechanoreceptors. Despite perceptual similarities between touch to different body sites, it is likely that the touch information is processed differently. In the present study, we used functional magnetic resonance imaging (fMRI) to elucidate the cortical differences in the neural signal of touch representations during active, self-touch and passive touch from another, to both glabrous (palm) and hairy (arm) skin, where a soft brush was used as the stimulus. There were two active touch conditions, where the participant used the brush in their right hand to stroke either their left palm or arm. There were two similar passive, touch conditions where the experimenter used an identical brush to stroke the same palm and arm areas on the participant. Touch on the left palm elicited a large, significant, positive blood-oxygenation level dependence (BOLD) signal in right sensorimotor areas. Less extensive activity was found for touch to the arm. Separate somatotopical palm and arm representations were found in Brodmann area (BA) 3 of the right primary somatosensory cortex (SI) and in both these areas, active stroking gave significantly higher signals than passive stroking. Active, self-touch elicited a positive BOLD signal in a network of sensorimotor cortical areas in the left hemisphere, compared to the resting baseline. In contrast, during passive touch, a significant negative BOLD signal was found in the left SI. Thus, each of the four conditions had a unique cortical signature despite similarities in afferent signaling or evoked perception. It is hypothesized that attentional mechanisms play a role in the modulation of the touch signal in the right SI, accounting for the differences found between active and passive touch.
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影响因子：
11
作者：
ABBRUZZESE, G;RATTO, S;ABBRUZZESE, M
通讯作者：
ABBRUZZESE, M
DOI：
10.1113/jphysiol.2010.199471
发表时间：
2011-04-01
期刊：
The Journal of physiology
影响因子：
--
作者：
Ackerley R;Barnes GR
通讯作者：
Barnes GR
影响因子：
3.7
作者：
Eickhoff, S. B.;Grefkes, C.;Zilles, K.
通讯作者：
Zilles, K.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
5.3
作者：
Bjornsdotter, Malin;Loken, Line;Wessberg, Johan
通讯作者：
Wessberg, Johan