Inferring signalling networks from images.
Inferring signalling networks from images.
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DOI:
10.1111/jmi.12062
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发表时间:
2013-10
影响因子:
2
通讯作者:
Bakal C
中科院分区:
文献类型:
--
作者:
Evans L;Sailem H;Vargas PP;Bakal C
The mapping of signalling networks is one of biology’s most important goals. However, given their size, complexity and dynamic nature, obtaining comprehensive descriptions of these networks has proven extremely challenging. A fast and cost-effective means to infer connectivity between genes on a systems-level is by quantifying the similarity between high-dimensional cellular phenotypes following systematic gene depletion. This review describes the methodology used to map signalling networks using data generated in the context of RNAi screens.
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DOI:
10.1093/bioinformatics/btq046
发表时间:
2010-04-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
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