Polymer micelles with crystalline cores for thermally triggered release.
Polymer micelles with crystalline cores for thermally triggered release.
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DOI：
10.1021/la300895c
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发表时间：
2012-07-24
期刊：
影响因子：
--
通讯作者：
Nikles DE
中科院分区：
文献类型：
--
作者：
Glover AL;Nikles SM;Nikles JA;Brazel CS;Nikles DE
聚（乙二醇）-b-聚己内酯二嵌段共聚物在靶向的磁触发药物递送系统中的应用引起了人们对聚己内酯核相行为的研究。通过聚乙二醇单甲醚（Mn ~ 2，000）的醇末端的己内酯开环聚合制备了四种不同的二嵌段共聚物。临界胶束浓度取决于聚己内酯嵌段的聚合度，并且在2.9至41 mg/L的范围内。浓度高于临界胶束浓度的聚合物溶液的差示扫描量热曲线显示在40至45°C范围内的熔融吸热，表明聚己内酯核是半结晶的。芘被截留在胶束核心，而不干扰聚己内酯的结晶能力。当聚合物溶液被加热到胶束核的熔点以上时，芘自由离开核。临界胶束浓度和温度依赖性的动态光散射的温度依赖性的测量表明，胶束保持完整的聚己内酯核心的熔点以上的温度。
Interest in the use of poly(ethylene glycol)-b-polycaprolactone diblock copolymers in a targeted, magnetically triggered drug delivery system has led to this study of the phase behavior of the polycaprolactone core. Four different diblock copolymers were prepared by the ring opening polymerization of caprolactone from the alcohol terminus of poly(ethylene glycol) monomethylether, Mn ~ 2,000. The critical micelle concentration depended on the degree of polymerization for the polycaprolactone block and was in the range of 2.9 to 41 mg/L. Differential scanning calorimetry curves for polymer solutions with a concentration above the critical micelle concentration showed a melting endotherm in the range of 40 to 45°C, indicating the polycaprolactone core was semicrystalline. Pyrene was entrapped in the micelle core without interfering with the ability of the polycaprolactone to crystallize. When the polymer solution was heated above the melting point of the micelle core, the pyrene was free to leave the core. Temperature dependent measurements of the critical micelle concentration and temperature dependent dynamic light scattering showed the micelles remain intact at temperatures above the melting point of the polycaprolactone core.
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影响因子：
15
作者：
KALYANASUNDARAM, K;THOMAS, JK
通讯作者：
THOMAS, JK
影响因子：
10.8
作者：
Shuai, XT;Ai, H;Gao, JM
通讯作者：
Gao, JM
影响因子：
10.8
作者：
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通讯作者：
Kwon, GS
DOI：
10.1007/s10856-006-0101-2
发表时间：
2008-01-01
影响因子：
3.7
作者：
Estelles, Jorge Mas;Vidaurre, Ana;Cortazar, Isabel Castilla
通讯作者：
Cortazar, Isabel Castilla
影响因子：
3.9
作者：
Heald, CR;Stolnik, S;Gellert, PR
通讯作者：
Gellert, PR