Activation of transcription factors by extracellular nucleotides in immune and related cell types.
Activation of transcription factors by extracellular nucleotides in immune and related cell types.
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免疫和相关细胞类型中细胞外核苷酸的转录因子激活。
DOI：
10.1007/s11302-006-9037-8
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发表时间：
2007-03
影响因子：
3.5
通讯作者：
Dixon, S. Jeffrey
中科院分区：
文献类型：
--
作者：
Armstrong, Souzan;Korcok, Jasminka;Sims, Stephen M.;Dixon, S. Jeffrey
细胞外核苷酸通过P2受体起作用，可以通过控制转录因子活性的细胞内信号通路来调节基因表达。关于免疫细胞中核苷酸对转录因子的激活作用，我们知之甚少。转录因子NF-κB家族在许多免疫和炎症反应中起关键作用。从受损或应激细胞释放的核苷酸可以通过某些P2受体单独作用以改变NF-κB活性，或者它们可以增强由病原体相关分子如LPS诱导的应答。核苷酸还显示调节免疫和相关细胞类型中的其他转录因子（AP-1、NFAT、CREB和STAT）的活性。在这里，我们提供了一个概述的转录因子被激活的核苷酸在免疫细胞中，并描述了什么是已知的激活机制和潜在的功能。此外，我们提出了在这一新的和不断扩大的领域今后工作的领域。
Extracellular nucleotides, acting through P2 receptors, can regulate gene expression via intracellular signaling pathways that control the activity of transcription factors. Relatively little is known about the activation of transcription factors by nucleotides in immune cells. The NF-κB family of transcription factors is critical for many immune and inflammatory responses. Nucleotides released from damaged or stressed cells can act alone through certain P2 receptors to alter NF-κB activity or they can enhance responses induced by pathogen-associated molecules such as LPS. Nucleotides have also been shown to regulate the activity of other transcription factors (AP-1, NFAT, CREB and STAT) in immune and related cell types. Here, we provide an overview of transcription factors shown to be activated by nucleotides in immune cells, and describe what is known about their mechanisms of activation and potential functions. Furthermore, we propose areas for future work in this new and expanding field.
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影响因子：
4
作者：
Hess, J;Angel, P;Schorpp-Kistner, M
通讯作者：
Schorpp-Kistner, M
影响因子：
4.9
作者：
Ivashkiv LB;Hu X
通讯作者：
Hu X
影响因子：
7.3
作者：
Beigi, RD;Kertesy, SB;Dubyak, GR
通讯作者：
Dubyak, GR
影响因子：
3.3
作者：
Brautigam, VM;Frasier, C;Watters, JJ
通讯作者：
Watters, JJ
免疫系统中的嘌呤能机制：树突状细胞的危险信号。
影响因子：
3.5
作者：
Di Virgilio, Francesco
通讯作者：
Di Virgilio, Francesco