Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements.
Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements.
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DOI：
10.1371/journal.pone.0025254
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Barault L
中科院分区：
文献类型：
--
作者：
Michels KB;Harris HR;Barault L
低出生体重、早产、宫内发育迟缓和母体营养不良与日后患心血管疾病、2型糖尿病、肥胖和神经精神疾病的风险增加有关。相反，高出生体重与未来患癌症的风险有关。通过基因组中重复序列的甲基化估计的整体DNA甲基化是慢性疾病易感性的指标。我们使用表观遗传出生队列的数据和生物标本，探讨319对母子中胎儿和母亲体重轨迹与LINE-1甲基化之间的关联。在调整胎龄、婴儿性别、母亲分娩年龄和母亲怀孕期间吸烟后，低出生体重或高出生体重的新生儿脐带血中LINE-1甲基化水平显著低于正常体重的婴儿（分别为p= 0.007和p =0.036），但差异幅度很小。 早产儿的脐带血中LINE-1甲基化水平也低于足月儿，这种差异虽然很小，但具有统计学意义（p = 0.004）。 我们没有发现母亲孕前BMI或妊娠期体重增加与脐带血或胎儿胎盘组织整体甲基化之间存在重要联系。总之，我们发现低出生体重和高出生体重的新生儿以及早产儿的脐带血LINE-1甲基化存在显著差异。未来的研究可能会阐明这些变化的染色体不稳定性或其他功能后果是否会导致具有这些特征的个体患慢性病的风险增加。
Low birthweight, premature birth, intrauterine growth retardation, and maternal malnutrition have been related to an increased risk of cardiovascular disease, type 2 diabetes mellitus, obesity, and neuropsychiatric disorders later in life. Conversely, high birthweight has been linked to future risk of cancer. Global DNA methylation estimated by the methylation of repetitive sequences in the genome is an indicator of susceptibility to chronic diseases. We used data and biospecimens from an epigenetic birth cohort to explore the association between trajectories of fetal and maternal weight and LINE-1 methylation in 319 mother-child dyads. Newborns with low or high birthweight had significantly lower LINE-1 methylation levels in their cord blood compared to normal weight infants after adjusting for gestational age, sex of the child, maternal age at delivery, and maternal smoking during pregnancy (p = 0.007 and p = 0.036, respectively), but the magnitude of the difference was small. Infants born prematurely also had lower LINE-1 methylation levels in cord blood compared to term infants, and this difference, though small, was statistically significant (p = 0.004). We did not find important associations between maternal prepregnancy BMI or gestational weight gain and global methylation of the cord blood or fetal placental tissue. In conclusion, we found significant differences in cord blood LINE-1 methylation among newborns with low and high birthweight as well as among prematurely born infants. Future studies may elucidate whether chromosomal instabilities or other functional consequences of these changes contribute to the increased risk of chronic diseases among individuals with these characteristics.
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影响因子：
64.8
作者：
MORSE, B;ROTHERG, PG;ASTRIN, SM
通讯作者：
ASTRIN, SM
影响因子：
3.8
作者：
McMinn, J.;Wei, M.;Tycko, B.
通讯作者：
Tycko, B.
影响因子：
--
作者：
Adkins RM;Thomas F;Tylavsky FA;Krushkal J
通讯作者：
Krushkal J
宫内生长限制后，新生儿的胞嘧啶甲基化失调。
影响因子：
3.7
作者：
Einstein F;Thompson RF;Bhagat TD;Fazzari MJ;Verma A;Barzilai N;Greally JM
通讯作者：
Greally JM
影响因子：
15.1
作者：
Bollati, V.;Galimberti, D.;Pergoli, L.;Dalla Valle, E.;Barretta, F.;Cortini, F.;Scarpini, E.;Bertazzi, P. A.;Baccarelli, A.
通讯作者：
Baccarelli, A.