The twilight zone: plasticity and mixed ontogeny of neutrophil and eosinophil granulocyte subsets.
The twilight zone: plasticity and mixed ontogeny of neutrophil and eosinophil granulocyte subsets.
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过渡带：中性粒细胞和嗜酸性粒细胞亚群的可塑性和混合个体发育。
DOI：
10.1007/s00281-021-00862-z
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发表时间：
2021-06
影响因子：
9
通讯作者：
Berdnikovs S
中科院分区：
文献类型：
--
作者：
Berdnikovs S
现在越来越清楚的是，中性粒细胞和嗜酸性粒细胞是异质细胞，在健康和疾病中可能有多个亚群。随着多色流式细胞术和粒细胞群体单细胞水平测序的标记物覆盖率增加，这些细胞的新表型开始出现。有趣的是，许多新描述的亚群混合了经典髓系表型之间的区别，这对于炎症和疾病背景下的组织常驻或募集细胞尤其如此。这包括嗜酸性粒细胞、单核细胞和树突状细胞特征的中性粒细胞的报道，以及表达中性粒细胞标记物的嗜酸性粒细胞亚群。此外，新的研究表明，未成熟的中性粒细胞能够转分化为属于其他髓系的成熟细胞（嗜酸性粒细胞，单核细胞/巨噬细胞）。在这篇综述中，我们总结了这一令人兴奋的研究前沿的新发现，并阐明了驱动粒细胞亚群可塑性和异质性的潜在过程。具体来说，我们讨论了骨髓中粒细胞前体的造血灵活性和骨髓细胞对局部组织微环境的适应性。了解这种中间和发育表型是非常重要的，因为它可以告诉我们炎症期间功能不同的骨髓细胞的起源，并解释针对终末分化粒细胞的生物制剂的成功和失败的原因。
It is now becoming clear that neutrophils and eosinophils are heterogeneous cells with potentially multiple subsets in health and disease. With greater marker coverage by multi-color flow cytometry and single-cell level sequencing of granulocyte populations, novel phenotypes of these cells began to emerge. Intriguingly, many newly described subsets blend distinctions between classical myeloid lineage phenotypes, which are especially true for tissue resident or recruited cells in contexts of inflammation and disease. This includes reports of neutrophils with features of eosinophils, monocytes and dendritic cells, and eosinophil subsets expressing neutrophil markers. Moreover, novel studies show the ability of immature neutrophils to transdifferentiate into mature cells belonging to other myeloid lineages (eosinophils, monocytes/macrophages). In this review, we summarize novel findings in this exciting research frontier and shed light on potential processes driving the plasticity and heterogeneity of granulocyte subsets. Specifically, we discuss the hematopoietic flexibility of granulocyte precursors in bone marrow and the adaptation of myeloid cells to local tissue microenvironments. The understanding of such intermediate and developmental phenotypes is very important, as it can teach us about origins of functionally distinct myeloid cells during inflammation, and explain reasons for successes and failures of biologics targeting terminally differentiated granulocytes.
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影响因子：
7.3
作者：
Ding ZC;Aboelella NS;Bryan L;Shi H;Zhou G
通讯作者：
Zhou G
DOI：
10.1111/j.1749-6632.2012.06607.x
发表时间：
2012-01-01
期刊：
HEMATOPOIETIC STEM CELLS VIII
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Bouffi, Carine;Kartashov, Andrey V.;Fulkerson, Patricia C.
通讯作者：
Fulkerson, Patricia C.
影响因子：
5.5
作者：
De Filippo K;Rankin SM
通讯作者：
Rankin SM
DOI：
10.1016/j.bbrc.2016.11.086
发表时间：
2017-01-15
影响因子：
3.1
作者：
Benarafa, Charaf;Simon, Hans-Uwe
通讯作者：
Simon, Hans-Uwe