Association of SNP rs6903956 on chromosome 6p24.1 with angiographical characteristics of coronary atherosclerosis in a Chinese population.
Association of SNP rs6903956 on chromosome 6p24.1 with angiographical characteristics of coronary atherosclerosis in a Chinese population.
复制标题
6p24.1染色体上的SNP Rs6903956与中国人群冠状动脉粥样硬化血管造影特征的关系
DOI：
10.1371/journal.pone.0043732
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ma WZ
中科院分区：
文献类型：
--
作者：
Guo CY;Gu Y;Li L;Jia EZ;Li CJ;Wang LS;Yang ZJ;Cao KJ;Ma WZ
目的探讨中国人群rs6903956基因与冠状动脉疾病严重程度的关系。方法对1075例疑似或已知冠状动脉粥样硬化的患者进行冠状动脉造影。冠状动脉粥样硬化严重程度由Gensini评分系统和病变血管计数确定。结果rs6903956位点GG、AG、AA基因型组间Gensini评分频率和病变血管计数存在差异（Gensini评分频率p=0.025，病变血管计数p=0.024）。 单变量logistic回归分析显示，该SNP的基因型分布与冠状动脉粥样硬化风险的血管造影特征显著相关（AG vs. GG，p= 0.030，比值比（OR）= 1.444，95%置信区间（CI）=1.036 <$2.013; AA vs. GG，p = 0.021，OR = 5.896，95% CI =1.299 <$26.750; AG+AA vs. GG，p= 0.007，OR = 1.564，95% CI =1.132 <$2.162）。 多因素Logistic回归分析显示rs6903956多态性的基因型分布与冠状动脉粥样硬化危险性的血管造影特征显著相关（GG vs. AG vs. AA p = 0.004，OR = 1.578，95%CI =1.155 <$2.154; GG vs. GA+ AA p = 0.013，OR = 1.541，95%CI =1.097 <$2.163）。 分层分析显示，在Gensini评分较高的受试者中，男性受试者和吸烟受试者的rs6903956杂合突变频率高于Gensini评分较低的受试者（男性亚组p= 0.023，OR = 1.579，95%CI =1.064 <$2.344;吸烟亚组p= 0.005，OR = 2.075，95%CI =1.249 <$3.448）。 结论A等位基因是冠心病的危险因素，rs6903956等位基因G → A可能与冠心病的发生有关。
Objective To explore the association between rs6903956 and severity of coronary artery disease (CAD) in a Chinese population. Methods A cohort of 1075 consecutive patients who underwent coronary arteriography for suspected or known coronary atherosclerosis was enrolled in our study. Coronary atherosclerosis severity was defined by Gensini's Score System and counts of diseased vessels. Results Gensini score frequencies and counts of diseased vessels differed among GG, AG, AA genotype groups at the rs6903956 locus (p = 0.025 for Gensini score frequencies vs. p = 0.024 for counts of diseased vessels, respectively). A univariate logistic regression analysis revealed that the genotype distribution of this SNP was associated significantly with angiographical characteristics of coronary atherosclerosis risk (p = 0.030, odds ratio (OR) = 1.444, 95% confidence interval (CI) = 1.036∼2.013 for AG vs. GG; p = 0.021, OR = 5.896, 95% CI = 1.299∼26.750 for AA vs. GG and p = 0.007, OR = 1.564, 95% CI = 1.132∼2.162 for combined (AG+AA) vs. GG). A multivariate logistic regression analysis indicated that the genotype distribution of the rs6903956 polymorphism be associated significantly with the angiographical characteristics of coronary atherosclerosis risk (p = 0.004, OR = 1.578, 95% CI = 1.155∼2.154 for GG vs. AG vs. AA; p = 0.013, OR = 1.541, 95% CI = 1.097∼2.163 for GG vs. GA+ AA). A stratification analysis revealed that male subjects and smoking subjects had a higher frequency of the rs6903956 heterozygous mutant among higher Gensini score subjects than among lower Gensini score subjects (p = 0.023, OR = 1.579, 95% CI = 1.064∼2.344 for male subgroup; p = 0.005, OR = 2.075, 95% CI = 1.249∼3.448 for smoking subgroup). Conclusions Allele A is a risk factor for CAD and the G-to-A allele substitution may underlie the association between rs6903956 and CAD.
登录
查看更多内容
吸烟与冠状动脉粥样硬化：中国的后续研究
DOI：
10.1111/j.1440-1681.2008.05134.x
发表时间：
2009-07-01
影响因子：
2.9
作者：
Jia, En-Zhi;Liang, Jun;Ma, Wen-Zhu
通讯作者：
Ma, Wen-Zhu
DOI：
10.1161/circgenetics.111.960096
发表时间：
2011-12
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Franceschini N;Carty C;Bůzková P;Reiner AP;Garrett T;Lin Y;Vöckler JS;Hindorff LA;Cole SA;Boerwinkle E;Lin DY;Bookman E;Best LG;Bella JN;Eaton C;Greenland P;Jenny N;North KE;Taverna D;Young AM;Deelman E;Kooperberg C;Psaty B;Heiss G
通讯作者：
Heiss G
影响因子：
168.9
作者：
Charchar, Fadi J.;Bloomer, Lisa D. S.;Barnes, Timothy A.;Cowley, Mark J.;Nelson, Christopher P.;Wang, Yanzhong;Denniff, Matthew;Debiec, Radoslaw;Christofidou, Paraskevi;Nankervis, Scott;Dominiczak, Anna F.;Bani-Mustafa, Ahmed;Balmforth, Anthony J.;Hall, Alistair S.;Erdmann, Jeanette;Cambien, Francois;Deloukas, Panos;Hengstenberg, Christian;Packard, Chris;Schunkert, Heribert;Ouwehand, Willem H.;Ford, Ian;Goodall, Alison H.;Jobling, Mark A.;Samani, Nilesh J.;Tomaszewski, Maciej
通讯作者：
Tomaszewski, Maciej
影响因子：
6.2
作者：
Dandona, Sonny;Stewart, Alexandre F. R.;Roberts, Robert
通讯作者：
Roberts, Robert
全基因组关联确定了中国汉族人群冠状动脉疾病的易感位点
影响因子：
30.8
作者：
Wang, Fan;Xu, Cheng-Qi;Wang, Qing K.
通讯作者：
Wang, Qing K.