Nuclear export of messenger RNA.
Nuclear export of messenger RNA.
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DOI：
10.3390/genes6020163
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发表时间：
2015-03-31
期刊：
影响因子：
3.5
通讯作者：
Katahira J
中科院分区：
文献类型：
--
作者：
Katahira J
信使RNA (mRNA)从细胞核转运至细胞质是真核基因表达的重要步骤。在细胞核中，前体 mRNA 经历一系列加工步骤，包括 5' 末端加帽、3' 末端剪接和切割/聚腺苷酸化。在此过程中，mRNA 与多种蛋白质结合，形成信使核糖核蛋白 (mRNP) 颗粒。与核输出相关因子的关联也在转录和加工过程中发生，因此核输出完全整合到 mRNA 成熟中。 mRNA 成熟和核输出之间的耦合是向细胞质翻译机制仅提供功能齐全且有能力的 mRNA 的重要机制，从而确保基因表达的准确性和快速性。这篇综述描述了主要转运因子（包括 Tap-p15 和 TREX 复合物）介导的核 mRNA 输出的分子机制。
Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex.
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