Modulation-specific and laminar-dependent effects of acetylcholine on visual responses in the rat primary visual cortex.
Modulation-specific and laminar-dependent effects of acetylcholine on visual responses in the rat primary visual cortex.
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DOI：
10.1371/journal.pone.0068430
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sato H
中科院分区：
文献类型：
--
作者：
Soma S;Shimegi S;Suematsu N;Tamura H;Sato H
乙酰胆碱 (ACh) 从基底前脑的胆碱能神经元分泌到整个大脑皮层区域，包括初级视觉皮层 (V1)，并通过一种称为容量传输的弥散性突触外调制影响所有六层的神经元活动。为了了解 V1 中的这种效应，我们对麻醉大鼠 V1 皮质层的漂移正弦光栅刺激的神经元反应进行了细胞外多点记录，并检查了局部施用 ACh 的调节作用。 ACh 促进或抑制具有层流偏差的单个细胞的视觉反应：反应抑制在第 2/3 层占主导地位，而反应促进在第 5 层占主导地位。ACh 对刺激对比反应函数的影响表明，ACh 分别在促进或抑制细胞中向上或向下改变反应增益。接下来，测试了 ACh 对信噪比 (S/N) 和光栅相位信息的影响。光栅相位信息计算为 F1/F0 比率，它表示漂移光栅基频 (F1) 相对于平均诱发响应 (F0) 的时间响应调制量。在受促进的细胞中，ACh 提高了 S/N 比，而在受抑制的细胞中，ACh 提高了 F1/F0 比，但同时没有降低 S/N 比。这些效应主要在常规尖峰细胞中观察到，但在快速尖峰细胞中观察不到。电生理学和组织学研究结果表明，ACh 通过对颗粒上层的抑制作用促进光栅相位信息向高阶区域的信号传导，并通过对颗粒下层的促进作用以高信噪比增强到皮层下区域的反馈信号。因此，ACh 以特定于调制和细胞类型且也是层流依赖性的方式清楚且精细地控制视觉信息处理。
Acetylcholine (ACh) is secreted from cholinergic neurons in the basal forebrain to regions throughout the cerebral cortex, including the primary visual cortex (V1), and influences neuronal activities across all six layers via a form of diffuse extrasynaptic modulation termed volume transmission. To understand this effect in V1, we performed extracellular multi-point recordings of neuronal responses to drifting sinusoidal grating stimuli from the cortical layers of V1 in anesthetized rats and examined the modulatory effects of topically administered ACh. ACh facilitated or suppressed the visual responses of individual cells with a laminar bias: response suppression prevailed in layers 2/3, whereas response facilitation prevailed in layer 5. ACh effects on the stimulus contrast-response function showed that ACh changes the response gain upward or downward in facilitated or suppressed cells, respectively. Next, ACh effects on the signal-to-noise (S/N) ratio and the grating-phase information were tested. The grating-phase information was calculated as the F1/F0 ratio, which represents the amount of temporal response modulation at the fundamental frequency (F1) of a drifting grating relative to the mean evoked response (F0). In facilitated cells, ACh improved the S/N ratio, while in suppressed cells it enhanced the F1/F0 ratio without any concurrent reduction in the S/N ratio. These effects were predominantly observed in regular-spiking cells, but not in fast-spiking cells. Electrophysiological and histological findings suggest that ACh promotes the signaling of grating-phase information to higher-order areas by a suppressive effect on supragranular layers and enhances feedback signals with a high S/N ratio to subcortical areas by a facilitatory effect on infragranular layers. Thus, ACh distinctly and finely controls visual information processing in a manner that is specific for the modulation and cell type and is also laminar dependent.
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影响因子：
3.3
作者：
ECKENSTEIN, FP;BAUGHMAN, RW;QUINN, J
通讯作者：
QUINN, J
影响因子：
2.5
作者：
Disney, Anita A.;Domakonda, Kunal V.;Aoki, Chiye
通讯作者：
Aoki, Chiye
影响因子：
5.3
作者：
Bereshpolova, Y;Stoelzel, CR;Swadlow, HA
通讯作者：
Swadlow, HA
影响因子：
3.7
作者：
Lucas-Meunier, Estelle;Monier, Cyril;Fossier, Philippe
通讯作者：
Fossier, Philippe
DOI：
10.1196/annals.1417.026
发表时间：
2008-01-01
期刊：
MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION
影响因子：
--
作者：
Jones, Barbara E.
通讯作者：
Jones, Barbara E.