The distributed annotation system.

The distributed annotation system.
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DOI:
10.1186/1471-2105-2-7
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发表时间:
2001
期刊:
影响因子:
3
通讯作者:
Stein L
Stein L
中科院分区:
生物学4区
文献类型:
--
作者:
Dowell RD;Jokerst RM;Day A;Eddy SR;Stein L

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目前,大多数基因组注释都是由资源有限的集中群体策划的。在多个小组之间透明地分享注释的努力尚不令人满意。 在这里,我们介绍了一个称为分布式注释系统(DAS)的概念。 DAS允许将序列注释分散在多个第三方注释中,并按照客户端软件的基础进行集成。 DAS XML规范定义了DAS中客户端和服务器之间的通信。注释以分层显示,每台服务器一层。遵守DAS XML规范的任何客户端或服务器都可以参与系统;我们描述了一个简单的原型客户端和服务器示例。 DAS规范通过Ensembl,Wormbase和Berkeley果蝇基因组项目实验使用。持续的成功将取决于研究社区采用DA和提供注释的准备。所有组件均可以从项目网站免费获得。
Currently, most genome annotation is curated by centralized groups with limited resources. Efforts to share annotations transparently among multiple groups have not yet been satisfactory. Here we introduce a concept called the Distributed Annotation System (DAS). DAS allows sequence annotations to be decentralized among multiple third-party annotators and integrated on an as-needed basis by client-side software. The communication between client and servers in DAS is defined by the DAS XML specification. Annotations are displayed in layers, one per server. Any client or server adhering to the DAS XML specification can participate in the system; we describe a simple prototype client and server example. The DAS specification is being used experimentally by Ensembl, WormBase, and the Berkeley Drosophila Genome Project. Continued success will depend on the readiness of the research community to adopt DAS and provide annotations. All components are freely available from the project website .
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