Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study.
Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study.
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DOI：
10.3390/microorganisms10030519
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发表时间：
2022-02-27
期刊：
影响因子：
4.5
通讯作者：
Lupu F
中科院分区：
文献类型：
--
作者：
Chaaban H;Patel MM;Burge K;Eckert JV;Lupu C;Keshari RS;Silasi R;Regmi G;Trammell M;Dyer D;McElroy SJ;Lupu F
越来越多的证据表明，早产儿长期抗生素治疗与死亡率和发病率增加相关，如坏死性小肠结肠炎（NEC），一种以肠道炎症和坏死为特征的破坏性胃肠道病理学。虽然抗生素的使用与NEC的发生之间存在临床相关性，但抗生素在NEC发生中的潜在因果关系尚未得到证实。在这里，我们测试了10天的全身标准护理抗生素治疗对新生小鼠肠道发育的影响。全身抗生素治疗通过减少肠细胞增殖、绒毛高度、隐窝深度以及杯状细胞和潘氏细胞数量来损害肠发育。接受抗生素的幼鼠的口腔细菌挑战导致超过一半的幼鼠出现NEC样肠损伤，这可能是由于影响微生物-上皮相互作用的粘液产生细胞减少。这些数据支持了一种新的机制，可以解释为什么早产儿出生后长期接触抗生素会导致NEC和其他胃肠道疾病的发生率较高。
Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by intestinal inflammation and necrosis. While a clinical correlation exists between antibiotic use and the development of NEC, the potential causality of antibiotics in NEC development has not yet been demonstrated. Here, we tested the effects of systemic standard-of-care antibiotic therapy for ten days on intestinal development in neonatal mice. Systemic antibiotic treatment impaired the intestinal development by reducing intestinal cell proliferation, villi height, crypt depth, and goblet and Paneth cell numbers. Oral bacterial challenge in pups who received antibiotics resulted in NEC-like intestinal injury in more than half the pups, likely due to a reduction in mucous-producing cells affecting microbial–epithelial interactions. These data support a novel mechanism that could explain why preterm infants exposed to prolonged antibiotics after birth have a higher incidence of NEC and other gastrointestinal disorders.
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影响因子：
6.7
作者：
Bergstrom KS;Kissoon-Singh V;Gibson DL;Ma C;Montero M;Sham HP;Ryz N;Huang T;Velcich A;Finlay BB;Chadee K;Vallance BA
通讯作者：
Vallance BA
影响因子：
28.3
作者：
Gibson, Molly K.;Wang, Bin;Ahmadi, Sara;Burnham, Carey-Ann D.;Tarr, Phillip I.;Warner, Barbara B.;Dantas, Gautam
通讯作者：
Dantas, Gautam
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
4.2
作者：
Duffy, LC
通讯作者：
Duffy, LC
影响因子：
2.9
作者：
Claud, Erika C.;Walker, W. Allan
通讯作者：
Walker, W. Allan