Chemical exchange sensitive MRI of glucose uptake using xylose as a contrast agent.
Chemical exchange sensitive MRI of glucose uptake using xylose as a contrast agent.
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DOI：
10.1002/mrm.28557
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发表时间：
2021-04
影响因子：
3.3
通讯作者：
Jin T
中科院分区：
文献类型：
--
作者：
Wang J;Fukuda M;Chung JJ;Wang P;Jin T
葡萄糖及其类似物可以通过化学交换饱和转移（CEST）和自旋锁（CESL）MRI技术检测，但灵敏度仍然是人体应用的瓶颈。在此，评价了葡萄糖类似物木糖的CESL和CEST敏感性以及注射对基线生理学的影响。CEST和CESL的敏感性在9.4 T的幻影和体内大鼠实验中用0.5和1 g/kg木糖注射进行了评价。在注射1 g/kg木糖之前和之后对动脉血糖水平进行采样。在注射生理盐水、木糖和2-脱氧-D-葡萄糖（2DG）期间，通过电生理学数据测量注射对基线神经元活性的影响。在phantomy中，木糖显示出与葡萄糖相似的化学交换敏感性和pH依赖性。在大鼠推注实验中，CESL在检测木糖方面显示出比CEST更高的灵敏度，并且木糖的灵敏度比葡萄糖高得多。注射木糖分别对1 g/kg和0.6 g/kg剂量的血糖水平和基线神经活动没有显著影响。由于其相对较高的敏感性和安全性，木糖是一种很有前途的葡萄糖摄取研究的造影剂。
Glucose and its analogs can be detected by chemical exchange saturation transfer (CEST) and spin-lock (CESL) MRI techniques, but sensitivity is still a bottleneck for human applications. Here CESL and CEST sensitivity and the effect of injection on baseline physiology were evaluated for a glucose analog, xylose. CEST and CESL sensitivity were evaluated at 9.4 T in phantoms and by in vivo rat experiments with 0.5 and 1 g/kg xylose injections. Arterial blood glucose level was sampled before and after 1 g/kg xylose injection. The effect of injection on baseline neuronal activity was measured by electrophysiology data during injections of saline, xylose, and 2-deoxy-D-glucose (2DG). In phantoms, xylose shows similar chemical exchange sensitivity and pH-dependence with that of glucose. In rat experiments with a bolus injection, CESL shows higher sensitivity in the detection of xylose than CEST, and the sensitivity of xylose is much higher than glucose. Injection of xylose does not significantly affect blood glucose level and baseline neural activity for 1 g/kg and 0.6 g/kg doses, respectively. Due to its relatively high sensitivity and safety, xylose is a promising contrast agent for the study of glucose uptake.
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影响因子：
3.3
作者：
Herz, Kai;Lindig, Tobias;Zaiss, Moritz
通讯作者：
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影响因子：
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