Regional impairments of cortical folding in premature infants.
Regional impairments of cortical folding in premature infants.
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DOI：
10.1002/ana.24313
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发表时间：
2015-01
影响因子：
11.2
通讯作者：
Neil, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Engelhardt, Erin;Inder, Terrie E.;Alexopoulos, Dimitrios;Dierker, Donna L.;Hill, Jason;Van Essen, David;Neil, Jeffrey J.
本研究旨在探讨早产及其他因素对大脑皮质成熟的影响。我们通过对52名早产儿（孕龄<31周，常规磁共振成像轻度或无损伤）和12名足月出生的对照婴儿应用皮质制图方法，评估了早产对皮质折叠的影响。所有婴儿均在足月月经后年龄进行评估。早产儿的脑回指数（GI; 2.06 ± 0.07 vs 1.80 ± 0.12，p < 0.001;对照组vs早产儿）和皮质表面积（CSA; 316 ± 24 cm 2 vs 257 ± 40 cm 2，p < 0.001）的整体测量值较低。脑沟深度和皮质形状的区域分析显示，早产对两个半球的颞侧沟、上级颞侧沟和中央前沟和中央后沟的腹侧部分的影响最大。虽然CSA和GI相关，但CSA对产前和产后因素的敏感性高于GI。这两项指标在出生体重标准差评分较低和扫描时枕额围较小的早产儿中均较低，而单独CSA与出生时枕额围较小相关。在出生后24小时内有较高危重病、暴露于出生后类固醇和延长气管插管的婴儿中，CSA也较低。早产以区域特异性方式破坏皮质发育，在月经后相当的时期明显异常。这种破坏受到产前生长和产后过程的影响。
This study was undertaken to evaluate the influence of preterm birth and other factors on cerebral cortical maturation. We have evaluated the effects of preterm birth on cortical folding by applying cortical cartography methods to a cohort of 52 preterm infants (<31 weeks gestation, mild or no injury on conventional magnetic resonance imaging) and 12 term-born control infants. All infants were evaluated at term-equivalent postmenstrual age. Preterm infants had lower values for the global measures of gyrification index (GI; 2.06 ± 0.07 vs 1.80 ± 0.12, p < 0.001; control vs preterm) and cortical surface area (CSA; 316 ± 24 cm2 vs 257 ± 40 cm2, p < 0.001). Regional analysis of sulcal depth and cortical shape showed the greatest impact of preterm birth on the insula, superior temporal sulcus, and ventral portions of the pre- and postcentral sulci in both hemispheres. Although CSA and GI are related, CSA was more sensitive to antenatal and postnatal factors than GI. Both measures were lower in preterm infants of lower birth weight standard deviation scores and smaller occipitofrontal circumference at time of scan, whereas CSA alone was lower in association with smaller occipitofrontal circumference at birth. CSA was also lower in infants with higher critical illness in the first 24 hours of life, exposure to postnatal steroids, and prolonged endotracheal intubation. Preterm birth disrupts cortical development in a regionally specific fashion with abnormalities evident by term-equivalent postmenstrual age. This disruption is influenced by both antenatal growth and postnatal course.
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影响因子：
8
作者：
H端ppi, PS;Murphy, B;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
14.5
作者：
Nosarti, Chiara;Giouroukou, Elena;Murray, Robin M.
通讯作者：
Murray, Robin M.
DOI：
10.1523/jneurosci.4682-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill J;Dierker D;Neil J;Inder T;Knutsen A;Harwell J;Coalson T;Van Essen D
通讯作者：
Van Essen D
影响因子：
3.7
作者：
Dubois, J.;Benders, M.;Hueppi, P. S.
通讯作者：
Hueppi, P. S.
影响因子：
4.8
作者：
Allen, Marilee C.
通讯作者：
Allen, Marilee C.