Interferon-inducible chemokines reflect severity and progression in sarcoidosis.
Interferon-inducible chemokines reflect severity and progression in sarcoidosis.
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DOI：
10.1186/1465-9921-14-121
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发表时间：
2013-11-07
影响因子：
5.8
通讯作者：
Koth LL
中科院分区：
文献类型：
--
作者：
Su R;Nguyen ML;Agarwal MR;Kirby C;Nguyen CP;Ramstein J;Darnell EP;Gomez AD;Ho M;Woodruff PG;Koth LL
识别与结节病病程相关的血清蛋白可能具有临床和病理学意义。我们之前发现，与对照组相比，结节病患者血液中干扰素诱导的趋化因子CXCL9和CXCL10的转录上调。这项研究的目的是确定这些转录本编码的蛋白质是否在血清中升高，并纵向识别缓解性和慢性进行性结节病患者。在结节病受试者和对照组的前瞻性队列中，检测了CXCL9、CXCL10以及与炎症和/或疾病活动相关的蛋白(sIL2R、ACE、ESR和CRP)的水平。使用肺功能测量和Wasfi等人开发的严重程度评分进行组间和临床病程之间的比较。在一项对36名非免疫抑制结节病患者的横断面分析中，与46名对照组相比，血清CXCL9、CXCL10和sIL2R显著升高(p <； 0.0001)。CXCL9和CXCL10之间有很强的相关性(p = 0.0009)。CXCL10和CXCL9分别与FVC%预测值和DLCO%预测值呈负相关。CXCL10和CXCL9与结节病严重程度评分显著相关。SIL2R、血沉、C反应蛋白和血管紧张素转换酶血清水平与肺功能指标或严重程度评分无关。在26名受试者的纵向分析中，血清CXCL10水平随时间的变化与疾病的进展和缓解相对应。干扰素-γ诱导的趋化因子CXCL9和CXCL10在结节病中升高，且相互关联。趋化因子水平与疾病严重程度的衡量标准相关。CXCL10系列测定与临床病程相符。
Identification of serum proteins that track with disease course in sarcoidosis may have clinical and pathologic importance. We previously identified up-regulated transcripts for interferon-inducible chemokines CXCL9, and CXCL10, in blood of sarcoidosis patients compared to controls. The objective of this study was to determine whether proteins encoded by these transcripts were elevated in serum and identified patients with remitting vs. chronic progressive sarcoidosis longitudinally. Serum levels of CXCL9, CXCL10, and proteins associated with inflammation and/or disease activity (sIL2R, ACE, ESR and CRP) were measured in a prospective cohort of sarcoidosis subjects and controls. Comparisons were made between groups and clinical course using pulmonary function measures and a severity score developed by Wasfi et al. In a cross-sectional analysis of 36 non-immunosuppressed sarcoidosis subjects, serum CXCL9, CXCL10, and sIL2R were significantly elevated compared to 46 controls (p < 0.0001). CXCL9 and CXCL10 were strongly inter-correlated (p = 0.0009). CXCL10 and CXCL9 were inversely correlated with FVC% predicted and DLCO% predicted, respectively. CXCL10 and CXCL9 significantly correlated with sarcoidosis severity score. sIL2R, ESR, CRP, and ACE serum levels did not correlate with pulmonary function measures or severity score. In the longitudinal analysis of 26 subjects, changes in serum CXCL10 level over time corresponded with progression versus remission of disease. Interferon-γ–inducible chemokines, CXCL9 and CXCL10, are elevated in sarcoidosis and inter-correlated with each other. Chemokine levels correlated with measures of disease severity. Serial measurements of CXCL10 corresponded to clinical course.
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DOI：
10.1080/00365510701854975
发表时间：
2008-01-01
影响因子：
2.1
作者：
Bargagli, Elena;Bianchi, Nicola;Rottoli, Paola
通讯作者：
Rottoli, Paola
DOI：
10.1164/rccm.200912-1855oc
发表时间：
2010-06-15
影响因子：
24.7
作者：
Lockstone, Helen E.;Sanderson, Sharon;Ho, Ling-Pei
通讯作者：
Ho, Ling-Pei
影响因子：
9.6
作者：
Antonelli, Alessandro;Fazzi, Piera;Ferrannini, Ele
通讯作者：
Ferrannini, Ele
影响因子：
3.7
作者：
Groom JR;Luster AD
通讯作者：
Luster AD
影响因子：
32.4
作者：
Groom JR;Richmond J;Murooka TT;Sorensen EW;Sung JH;Bankert K;von Andrian UH;Moon JJ;Mempel TR;Luster AD
通讯作者：
Luster AD