Rapid golden-angle diffusion-weighted propeller MRI for simultaneous assessment of ADC and IVIM.
Rapid golden-angle diffusion-weighted propeller MRI for simultaneous assessment of ADC and IVIM.
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DOI：
10.1016/j.neuroimage.2020.117327
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发表时间：
2020-12
期刊：
影响因子：
5.7
通讯作者：
Wu YC
中科院分区：
文献类型：
--
作者：
Wen Q;Feng L;Zhou K;Wu YC
提出了一种黄金角单次激发PROPLLER（GA-SS-PROP）方法，用于加速无失真扩散加权（DW）成像的PROPELLER采集。通过采集每个b值的一次激发来实现加速，并且可以沿着扩散方向采集多个b值，其中DW信号遵循双指数衰减（即IVIM）。稀疏重建用于重建全分辨率DW图像。因此，表观扩散系数（ADC）图和IVIM图（即，同时获得灌注分数（f）和无灌注扩散系数（D））。通过仿真和人体实验证明了GA-SS-PROP的性能。一个逼真的数字幻影的高品质的扩散图像的大脑。将重建的DW图像和定量图的误差与地面实况进行比较。脉冲序列是为了获取人脑数据而开发的。为了进行比较，进行了全采样PROPELLER和常规单次激发回波平面成像（SS-EPI）采集。GA-SS-PROP比传统PROPELLER采集快5倍，图像质量相当。仿真结果表明，稀疏重建在恢复对比度和分辨率方面是有效的。人体实验表明，在相同的采集时间和相同的面内分辨率（1 × 1 mm 2）下，GA-SS-PROP的图像保真度上级SS-EPI。GA-SS-PROP提供快速、高分辨率和无失真的DW图像。生成的定量图（f，D和ADC）可以同时提供有关组织灌注和扩散特性的有价值的信息，这在许多应用中是期望的，特别是在肿瘤学中。作为一种基于涡轮自旋回波的技术，它可以应用于SS-EPI存在问题的最具挑战性的区域。
Golden-angle single-shot PROPLLER (GA-SS-PROP) is proposed to accelerate the PROPELLER acquisition for distortion-free diffusion-weighted (DW) imaging. Acceleration is achieved by acquiring one-shot per b-value and several b-values can be acquired along a diffusion direction, where the DW signal follows a bi-exponential decay (i.e. IVIM). Sparse reconstruction is used to reconstruct full resolution DW images. Consequently, apparent diffusion coefficient (ADC) map and IVIM maps (i.e., perfusion fraction (f) and the perfusion-free diffusion coefficient (D)) are obtained simultaneously. The performance of GA-SS-PROP was demonstrated with simulation and human experiments. A realistic numerical phantom of high-quality diffusion images of the brain was developed. The error of the reconstructed DW images and quantitative maps were compared to the ground truth. The pulse sequence was developed to acquire human brain data. For comparison, fully sampled PROPELLER and conventional single-shot echo planar imaging (SS-EPI) acquisitions were performed. GA-SS-PROP was 5 times faster than conventional PROPELLER acquisition with comparable image quality. The simulation demonstrated that sparse reconstruction is effective in restoring contrast and resolution. The human experiments demonstrated that GA-SS-PROP achieved superior image fidelity compared to SS-EPI for the same acquisition time and same in-plane resolution (1 × 1 mm2). GA-SS-PROP offers fast, high-resolution and distortion-free DW images. The generated quantitative maps (f, D and ADC) can provide valuable information on tissue perfusion and diffusion properties simultaneously, which are desirable in many applications, especially in oncology. As a turbo spin-echo based technique, it can be applied in most challenging regions where SS-EPI is problematic.
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影响因子：
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