SNARE-mediated membrane fusion in autophagy.

SNARE-mediated membrane fusion in autophagy.
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DOI:
10.1016/j.semcdb.2016.07.009
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发表时间:
2016-12
影响因子:
7.3
通讯作者:
Diao, Jiajie
Diao, Jiajie
中科院分区:
生物学2区
文献类型:
--
作者:
Wang, Yongyao;Li, Linsen;Hou, Chen;Lai, Ying;Long, Jiangang;Liu, Jiankang;Zhong, Qing;Diao, Jiajie

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Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.
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