XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies.
XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies.
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DOI：
10.1371/journal.pone.0064851
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Shi YQ
中科院分区：
文献类型：
--
作者：
Bao Y;Jiang L;Zhou JY;Zou JJ;Zheng JY;Chen XF;Liu ZM;Shi YQ
以前的研究调查X射线修复交叉互补组1（XRCC 1）多态性与甲状腺癌风险之间的关联，结果不一致。进行这项荟萃分析是为了更精确地估计三个XRCC 1多态性与甲状腺癌风险之间的关系。系统检索PubMed和EMBASE数据库以识别相关研究。本荟萃分析共选取10篇文献，其中Arg 399 Gln多态性11篇（病例组1726例，对照组3774例），Arg 194 Trp多态性7篇（病例组1037例，对照组2487例），Arg 280 His多态性8篇（病例组1432例，对照组3356例）。在总人群中的结果并没有显示任何显着的关联，这三个多态性和DTC的风险，所有的遗传模型。然而，当按种族分层时，结果显示Arg 280 His多态性与白人中DTC风险增加相关（Arg/His vs. Arg/Arg：OR = 1.45，95%CI = 1.09-1.93;显性模型：OR = 1.43，95%CI = 1.08-1.89;加性模型：OR = 1.38，95%CI = 1.05-1.80），而携带Arg/His基因型的个体在亚洲人中DTC风险显著降低（Arg/His vs. Arg/Arg：OR = 0.71，95%CI = 0.51-0.98）。 在混合人群中，399 Gln变异等位基因携带者可能降低了DTC的发病风险。此外，按组织学亚型进行的亚组分析显示，Arg 194 Trp多态性与甲状腺乳头状癌（PTC）风险降低显著相关（显性模型：OR = 0.71，95%CI = 0.50-0.99）。 这项荟萃分析表明，Arg 280 His多态性可能有助于在白人中的DTC的易感性，而它可能提供保护作用，在亚洲人对DTC的风险。此外，我们的研究结果支持Arg 194 Trp多态性在PTC发展中的保护作用，并显示Arg 399 Gln多态性与混合人群中DTC风险降低之间存在关联的证据。
Previous studies investigating the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and thyroid cancer risk have yielded inconsistent results. This meta-analysis was performed to derive a more precise estimation of the relationship between three XRCC1 polymorphisms and thyroid cancer risk. PubMed and EMBASE database were systematically searched to identify relevant studies. 10 publications were selected for this meta-analysis, including 11 studies for Arg399Gln polymorphism (1726 cases and 3774 controls), 7 studies for Arg194Trp polymorphism (1037 cases and 2487 controls) and 8 studies for Arg280His polymorphism (1432 cases and 3356 controls). The results in total population did not show any significant association between these three polymorphisms and the risk of DTC for all genetic models. However, when stratified by ethnicity, the results showed that Arg280His polymorphism was associated with an increased risk of DTC among Caucasians (Arg/His vs. Arg/Arg: OR = 1.45, 95% CI = 1.09–1.93; dominant model: OR = 1.43, 95% CI = 1.08–1.89; additive model: OR = 1.38, 95% CI = 1.05–1.80), whereas individuals carrying Arg/His genotype have a significantly reduced risk of DTC among Asians (Arg/His vs. Arg/Arg: OR = 0.71, 95% CI = 0.51–0.98). We also detected that 399Gln variant allele carriers might presented an overall decreased risk of DTC in mixed population. Furthermore, subgroup analyses by histological subtype revealed that Arg194Trp polymorphism was significantly associated with reduced risk for papillary thyroid carcinoma (PTC) (dominant model: OR = 0.71, 95% CI = 0.50–0.99). This meta-analysis suggests that Arg280His polymorphism might contribute to the susceptibility of DTC among Caucasians, whereas it might provide protective effects in Asians against the risk of DTC. Additionally, our results support the protective role of Arg194Trp polymorphism in developing PTC, and show evidence of an association between Arg399Gln polymorphism and decreased risk of DTC in mixed population.
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影响因子：
11.4
作者：
Kubota, Y;Nash, RA;Lindahl, T
通讯作者：
Lindahl, T
影响因子：
2.8
作者：
Chen, Bo;Zhou, Yong;Wu, Xiao-Ting
通讯作者：
Wu, Xiao-Ting
影响因子：
5.3
作者：
CALDECOTT, KW;MCKEOWN, CK;THOMPSON, LH
通讯作者：
THOMPSON, LH
影响因子：
3
作者：
Monaco, Regina;Rosal, Ramon;Brandt-Rauf, Paul W.
通讯作者：
Brandt-Rauf, Paul W.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N